|
|
|
|
|
|
EFFECT OF HYDROGEN SULPHIDE DONOR ON INTRAOCULAR PRESSURE IN RATS
I.N. Mikheytseva, T.I. Siroshtanenko
The Filatov State Institute of Eye Diseases and Tissue
Therapy NAMS of Ukraine, Odesa
DOI: https://doi.org/10.15407/fz62.05.057
![](/images/cite.png)
Abstract
It has been investigated the effect of a 1% solution of sodium
hydrosulfide NaHS on intraocular pressure (IOP) in intact
rats and during modeling them of ocular hypertension, using
prolonged systemic administration of adrenaline. A single
administration of hydrogen sulphide donor as drops into cavity
of the eye has caused the hypotensive effect, which was pretty
weak in the normotensive eyes and pronounced in the eyes
with ocular hypertension. Long-term administration of NaHS
solution by the scheme, during administration of adrenaline
as a model inductor, has largely prevented IOP rise. It done
conclusion that hydrogen sulphide is involved in the regulation
of eye hydrodynamics and maintaining normal levels of IOP.
Keywords:
hydrogen sulphide; NaHS; ocular hypertension model; intraocular pressure; hypotensive effect.
References
- Kamoun P. Endogenous production of hydrogen sulfide in mammals. Amin Asids. 2004; 26:243-54.
CrossRef
- Abe K, Kimura H The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996; 16: 1066-71.
- Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun. 1997; 237: 527–31.
CrossRef
PubMed
- Tang G, Jang G, Wu L, Liang W, Wang R. Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol Pharmacol. 2005; 68: 1757—64.
- Wagner CA. Hydrogen sulfide: a new gaseous signal molecula and blood pressure regulator. J Nephrol. 2009; 22 (2): 173—6.
- Sagiraju Sowmya, Yada Swathi, Ai Ling Yeo et al. Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vasc Pharmacol. 2010; 53(3-4): 138-43.
- Ohia SE, Opere CA, Monjok EM, Kouamou G, Leday AM, Njie-Mbye YF. Role of hydrogen sulfide production in inhibitory action of L-cysteine on isolated porcine irides. Curr Eye Res. 2010; 35(5):402- 7.
CrossRef
PubMed
- Pong WW, Stouracova R, Frank N, Kraus JP, Eldred WD. Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals. J Comp Neurol. 2007; 505(2):158-65.
CrossRef
PubMed
- Persa C, Osmotherly K, Chao-Wei Chen K, Moon S, Lou MF. The distribution of cystathionine beta-synthase (CBS) in the eye: implication of the presence of a trans-sulfuration pathway for oxidative stress defense. Exp Eye Res. 2006; 83(4):817-23.
CrossRef
PubMed
- Shevalev VE. Hyperbolic ruler to measure tonogramm. Ophthalmol J. 1947; 3:140-144.
- Mikheytseva I. N. Glaucoma modeling and adrenalin stress. Clin Exp Med Res J. 2014; 4:427-37
- Mikheytseva I. N. Method of modeling of increased intraocular pressure in rats. Ukr. patent №38446, 2009.
- Kimura H, Nagai Y, Umenura K, Kimura Y. Physiological roles of hydrogen sulfide: synaptic modulation, neuroprotection, and smooth muscle relaxation. Antioxid Redox Signal. 2005;7:795–803.
CrossRef
PubMed
- Szabu¨ C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov. 2007; 6:917–35.
CrossRef
PubMed
- Kulkarni KH, Monjok EM, Zeyssig R, et al. Effect of hydrogen sulfide on sympathetic neurotransmission and catecholamine levels in isolated porcine iris-ciliary body. Neurochem Res. 2009; 34(3):400-6.
CrossRef
PubMed
- Monjok E, Kulkarni K et al. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides. Exp Eye Res. 2008; 87: 612 –6 .
CrossRef
PubMed
- Salvi A. Effect of hydrogen sulfide donors on sympathetic neurotransmission and intraocular pressure of the eye. Thesis of Dissertation, 2013.
|
|
|
|
|
|
|
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
|
|