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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(5): 57-61

EFFECT OF HYDROGEN SULPHIDE DONOR ON INTRAOCULAR PRESSURE IN RATS

I.N. Mikheytseva, T.I. Siroshtanenko

    The Filatov State Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine, Odesa
DOI: https://doi.org/10.15407/fz62.05.057


Abstract

It has been investigated the effect of a 1% solution of sodium hydrosulfide NaHS on intraocular pressure (IOP) in intact rats and during modeling them of ocular hypertension, using prolonged systemic administration of adrenaline. A single administration of hydrogen sulphide donor as drops into cavity of the eye has caused the hypotensive effect, which was pretty weak in the normotensive eyes and pronounced in the eyes with ocular hypertension. Long-term administration of NaHS solution by the scheme, during administration of adrenaline as a model inductor, has largely prevented IOP rise. It done conclusion that hydrogen sulphide is involved in the regulation of eye hydrodynamics and maintaining normal levels of IOP.

Keywords: hydrogen sulphide; NaHS; ocular hypertension model; intraocular pressure; hypotensive effect.

Full text: (PDF, in Ukrainian)

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