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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(5): 57-61


EFFECT OF HYDROGEN SULPHIDE DONOR ON INTRAOCULAR PRESSURE IN RATS

I.N. Mikheytseva, T.I. Siroshtanenko

    The Filatov State Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine, Odesa
DOI: https://doi.org/10.15407/fz62.05.057

Abstract

It has been investigated the effect of a 1% solution of sodium hydrosulfide NaHS on intraocular pressure (IOP) in intact rats and during modeling them of ocular hypertension, using prolonged systemic administration of adrenaline. A single administration of hydrogen sulphide donor as drops into cavity of the eye has caused the hypotensive effect, which was pretty weak in the normotensive eyes and pronounced in the eyes with ocular hypertension. Long-term administration of NaHS solution by the scheme, during administration of adrenaline as a model inductor, has largely prevented IOP rise. It done conclusion that hydrogen sulphide is involved in the regulation of eye hydrodynamics and maintaining normal levels of IOP.

Keywords: hydrogen sulphide; NaHS; ocular hypertension model; intraocular pressure; hypotensive effect.

References

  1. Kamoun P. Endogenous production of hydrogen sulfide in mammals. Amin Asids. 2004; 26:243-54. CrossRef  
  2. Abe K, Kimura H The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996; 16: 1066-71.
  3.  
  4. Hosoki R, Matsuki N, Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun. 1997; 237: 527–31. CrossRef PubMed
  5.  
  6. Tang G, Jang G, Wu L, Liang W, Wang R. Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol Pharmacol. 2005; 68: 1757—64.
  7.  
  8. Wagner CA. Hydrogen sulfide: a new gaseous signal molecula and blood pressure regulator. J Nephrol. 2009; 22 (2): 173—6.
  9.  
  10. Sagiraju Sowmya, Yada Swathi, Ai Ling Yeo et al. Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia. Vasc Pharmacol. 2010; 53(3-4): 138-43.
  11.  
  12. Ohia SE, Opere CA, Monjok EM, Kouamou G, Leday AM, Njie-Mbye YF. Role of hydrogen sulfide production in inhibitory action of L-cysteine on isolated porcine irides. Curr Eye Res. 2010; 35(5):402- 7. CrossRef PubMed
  13.  
  14. Pong WW, Stouracova R, Frank N, Kraus JP, Eldred WD. Comparative localization of cystathionine beta-synthase and cystathionine gamma-lyase in retina: differences between amphibians and mammals. J Comp Neurol. 2007; 505(2):158-65. CrossRef PubMed
  15.  
  16. Persa C, Osmotherly K, Chao-Wei Chen K, Moon S, Lou MF. The distribution of cystathionine beta-synthase (CBS) in the eye: implication of the presence of a trans-sulfuration pathway for oxidative stress defense. Exp Eye Res. 2006; 83(4):817-23. CrossRef PubMed
  17.  
  18. Shevalev VE. Hyperbolic ruler to measure tonogramm. Ophthalmol J. 1947; 3:140-144.
  19.  
  20. Mikheytseva I. N. Glaucoma modeling and adrenalin stress. Clin Exp Med Res J. 2014; 4:427-37
  21.  
  22. Mikheytseva I. N. Method of modeling of increased intraocular pressure in rats. Ukr. patent №38446, 2009.
  23.  
  24. Kimura H, Nagai Y, Umenura K, Kimura Y. Physiological roles of hydrogen sulfide: synaptic modulation, neuroprotection, and smooth muscle relaxation. Antioxid Redox Signal. 2005;7:795–803. CrossRef PubMed
  25.  
  26. Szabu¨ C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov. 2007; 6:917–35. CrossRef PubMed
  27.  
  28. Kulkarni KH, Monjok EM, Zeyssig R, et al. Effect of hydrogen sulfide on sympathetic neurotransmission and catecholamine levels in isolated porcine iris-ciliary body. Neurochem Res. 2009; 34(3):400-6. CrossRef PubMed
  29.  
  30. Monjok E, Kulkarni K et al. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides. Exp Eye Res. 2008; 87: 612 –6 . CrossRef PubMed
  31.  
  32. Salvi A. Effect of hydrogen sulfide donors on sympathetic neurotransmission and intraocular pressure of the eye. Thesis of Dissertation, 2013.
  33.  

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