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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(5): 37-44

Role of matrix metalloproteinase 9 and its tissue inhibitor 1 in development and prognosis of diabetic retinopathy

S.V. Ziablitsev1, A.V. Korobova2, O.V. Petrenko3, V.N. Serduk4, S.U. Mogilevsky3

  1. Ukranian science-practical center of endocrine surgery, transplantation of endocrine organs and tis- sue Health Ministry of Ukraine, Kyiv;
  2. M. Gorky Donetsk National Medical University, Krasny Liman;
  3. L.M. Shupik National medical academy of postgradual education, Kyiv;
  4. SE «Dnepropetrovsk Medical Academy Health Ministry of Ukraine», Dnipro
DOI: https://doi.org/10.15407/fz62.05.037


Abstract

The article presents the results of investigation of violations in the proteolysis system in patients with type 2 diabetes and diabetic retinopathy (DR). We studied the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the blood and in the intraocular fluid of patients with type 2 diabetes depending upon the stage of DR. We have established that the level of MMP-9 and TIMP-1 in the blood and in the intraocular fluid increased in patients with type 2 diabetes without signs of DR and with any stage of DR compared to the levels of these parameters in patients without diabetes. Increasing the levels of MMP-9 and TIMP-1 took place with increasing of DR severity and reached its maximum levels at the proliferative stage of DR. It was found that the levels of MMP-9 in the intraocular fluid and type 2 diabetes duration affected the probability of developing diabetic macular edema. At the level of MMP-9 ≥ 105 ng/ml and 2 diabetes duration ≥ 10 years, the probability of developing macular edema was 100%. As a result of the construction of predictive models it was found that the level of MMP-9 in the intraocular fluid, stage of DR at the beginning of observation and type 2 diabetes duration had influence on the probability of the development of proliferative DR over 4 years of follow-up. If the level of MMP-9 ≥ 100 ng/ml, type 2 diabetes duration ≥ 10 years and absence of DR at the beginning of observation were observed the probability of developing proliferative DR would compose 85.9%.

Keywords: proteolysis system; metalloproteinase-9; tissue inhibitor of matrix metalloproteinase-1; intraocular fluid; diabetic retinopathy.

Full text: (PDF, in English)

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