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Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=18">Fiziol. Zh. 2016;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=95">62(4):</a> 95-102
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(4): 95-102


INSULIN-LIKE GROWTH FACTOR 1 UNDER CONDITIONS OF THE BRAIN VASCULAR DISEASES

O.Yu. Harmatina

    State Institution “Institute of Neurosurgery named after acad. A.P.Romodanov of the National Academy of Medical Sciences of Ukraine”, Kyiv.
DOI: https://doi.org/10.15407/fz62.04.095

Abstract

The system insulin-like growth factors (IGF) occupies an important place in the development and growth of the central nervous system (CNS). Gene expression of insulin-like growth factor 1 (IGF-1) and IGF-1 receptor are represented in all parts of the brain and are heavily concentrated in the cerebral vessels. IGF-1 is involved in neuro-, angiogenesis, in the stimulation of cell proliferation, and repair responses to damage for both the central and peripheral nervous system. IGF-1 exerts antioxidant, anti-inflammatory and protective effects on the CNS. The review discusses the importance and the role of IGF-1 in vascular diseases of the brain, in particular, aneurysms, the ischemic stroke, the aneurysmal subarachnoid hemorrhage, as well as neuroprotection.

Keywords: insulin-like growth factor 1; cerebral blood vessels; aneurysms, stroke; subarachnoid hemorrhage.

References

  1. D'ErcoleAJ, Ye P, O'Kusky JR. Mutant mouse models of insulin-like growth factor actions in the central nervous system. Neuropeptides. 2002;36(2-3):209–20. CrossRef PubMed
  2.  
  3. Hwa V, Oh Y, Rosenfeld RG. The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocrinol Rev. 1999,20:761–87. CrossRef  
  4. Russo VC, Gluckman PD, Feldman EL, Werther GA. The insulin-like growth factor system and its pleiotropic functions in brain. Endocrinol Rev. 2005;26:916–43. CrossRef PubMed
  5.  
  6. Benarroch EE. Insulin-like growth factors in the brain and their potential clinical implications. Neurol. 2012;79:2148–53. CrossRef PubMed
  7.  
  8. Rietveld I, Janssen JA, van Rossum EF, HouwingDuistermaat JJ, Rivadeneira F, Hofman A, Pols HA, van Duijn CM, Lamberts SW. A polymorphic CA repeat in the IGF-I gene is associated with gender-specific differences in body height, but has no effect on the secular trend in body height. Clin Endocrinol (Oxf). 2004;61(2):195–203. CrossRef PubMed
  9.  
  10. Åberg D, Jood K, Blomstrand C, Jern C, Nilsson M, Isgaard J, Aberg ND. Serum IGF-I levels correlate to improvement of functional outcome after ischemic stroke. J Clin Endocrinol Metab. 2011;96(7):E1055–64. CrossRef PubMed
  11.  
  12. van Bunderen CC, van Nieuwpoort IC, van Schoor NM, Deeg DJ, Lips P, Drent ML. The association of serum insulin-like growth factor-I with mortality, cardiovascular disease, and cancer in the elderly: a population-based study. J Clin Endocrinol Metab. 2010;95:4616–24. CrossRef PubMed
  13.  
  14. Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res, 2003;13:113–70. CrossRef  
  15. Zamykal M, Martens T, Matschke J, Günther HS, Kathagen A, Schulte A, Peters R, Westphal M, Lamszus K. Inhibition of intracerebral glioblastoma growth by targeting the insulin-like growth factor 1 receptor involves different context-dependent mechanisms. Neuro Oncol. 2015;17(8):1076–85. CrossRef PubMed PubMedCentral
  16.  
  17. van Rijn MJ, Slooter AJ, Bos MJ, Catarino CF, Koudstaal PJ, Hofman A, Breteler MM, van Duijn CM. Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: The rotterdam study. J Neurol Neurosurg Psychiat. 2006;77:24-7. CrossRef PubMed PubMedCentral
  18.  
  19. Anisimov VN, Bartke A. The key role of growth hormoneinsulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol. 2013; 87(3):201-23. CrossRef PubMed PubMedCentral
  20.  
  21. Godau J, Herfurth M, Kattner B, Gasser T, Berg D. Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's disease. J Neurol Neurosurg Psychiat. 2010;81:536–8. CrossRef PubMed
  22.  
  23. Knapp J, Teschendorf P, Vogel P, Bruckner T, Böttiger BW, Popp E. Effects of intracerebroventricular application of insulin-like growth factor 1 and its N-terminal tripeptide on cerebral recovery following cardiac arrest in rats. Resuscitation. 2013;84(5):684–9. CrossRef PubMed
  24.  
  25. Sara VR, Carlsson-Skwirut C, Bergman T, Jornvall H, Roberts PJ, Crawford M, Hakansson LN, Civalero I, Nordberg A. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989; 165:766–71. CrossRef  
  26. Cacciatore I, Cornacchia C, Baldassarre L, Fornasari E, Mollica A, Stefanucci A, Pinnen F. GPE and GPE analogues as promising neuroprotective agents. Mini Rev Med Chem. 2012;12(1):13–23. CrossRef PubMed
  27.  
  28. Bondy CA, Lee WH. Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Functional implications. Ann N Y Acad Sci. 1993;692:33–43. CrossRef PubMed
  29.  
  30. Bondy CA, Werner H, Roberts Jr CT, LeRoith D. Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience. 1992;46:909–23. CrossRef  
  31. Bondy CA, Werner H, Roberts Jr CT, LeRoith D. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Mol Endocrinol. 1990;4:1386–98. CrossRef PubMed
  32.  
  33. Sonntag WE, Lynch CD, Bennett SA, Khan AS, Thornton PL, Cooney PT Ingram RL, McShane T, Brunso-Bechtold JK. Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience, 1999;88:269–79. CrossRef  
  34. Cun X, Xie J, Lin S, Fu N, Deng S, Xie Q, Zhong J, Lin Y. Gene profile of soluble growth factors involved in angiogenesis, in an adipose-derived stromal cell/endothelial cell co-culture, 3D gel model. Cell Prolif. 2015;48(4):405–12. CrossRef PubMed
  35.  
  36. Sato Y, Okamura K, Morimoto A, Hamanaka R, Hamaguchi K, Shimada T, Ono M, Kohno K, Sakata T, Kuwano M. Indispensable role of tissue-type plasminogen activator in growth factordependent tube formation of human microvascular endothelial cells in vitro. Exp Cell Res. 1993;204:223–9. CrossRef PubMed
  37.  
  38. Foster JA, Rich CB, Miller M, Benedict MR, Richman RA, Florini JR. Effect of age and IGF-I administration on elastin gene expression in rat aorta. J Gerontol. 1990;45:B113–8. CrossRef PubMed
  39.  
  40. Sonntag WE, Lynch CD, Cooney PT, Hutchins PM. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology. 1997;138:3515–20. CrossRef PubMed
  41.  
  42. Kulseng B, Myhre HO. Is insulin growth factor-1 (IGF-1) playing a role for aneurysm formation in patients with pituitary gland tumor? Int Angiol. 2006;25(4):433–5. PubMed
  43.  
  44. Manara R, Maffei P, Citton V, Rizzati S, Bommarito G, Ermani M, Albano I, Della Puppa A, Carollo C, Pavesi G, Scanarini M, Ceccato F, Sicolo N, Mantero F, Scaroni C, Martini C. Increased rate of intracranial saccular aneurysms in acromegaly: an MR angiography study and review of the literature. J Clin Endocrinol Metab. 2011;96(5):1292–300. CrossRef PubMed
  45.  
  46. Lindholt JS1, Martin-Ventura JL, Urbonavicius S, RamosMozo P, Flyvbjerg A, Egido J, Henneberg EW, Frystyk J. Insulin-like growth factor I - a novel biomarker of abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2011;42(5):560–2. CrossRef PubMed
  47.  
  48. Panek B, Gacko M, Pałka J. Metalloproteinases, insulin-like growth factor-I and its binding proteins in aortic aneurysm. Int J Exp Pathol. 2004;85(3):159–64. CrossRef PubMed PubMedCentral
  49.  
  50. Akturk IF1, Biyik I, Yalcin AA, Isiksacan N, Celik O, Ozturk D, Erturk M. Impact of insulin like growth factor-1 in development of coronary artery ectasia. Bosn J Basic Med Sci. 2014;14(4):244–9. CrossRef PubMed
  51.  
  52. Hochberg Z, Hertz P, Maor G, Oiknine J, Aviram M. Growth hormone and insulin-like growth factor I increase macrophage uptake and degradation of low-density lipoprotein. Endocrinology. 1992;131:430–5. CrossRef PubMed
  53.  
  54. Bayes-Genis A, Conover CA, Schwartz RS. The InsulinLike Growth Factor Axis A Review of Atherosclerosis and Restenosis. Circul Res. 2000;86:125–30. CrossRef  
  55. Binay C, Simsek E,Yıldırım A, Kosger P, Demiral M, Kılıç Z. Growth hormone and the risk of atherosclerosis in growth hormone-deficient children. Growth Horm IGF Res. 2015;25(6):294–7. CrossRef PubMed
  56.  
  57. Bennet MR, Evan GI, Schwartz SM. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest. 1995;95:2266–74. CrossRef PubMed PubMedCentral
  58.  
  59. Sukhanov S, Higashi Y, Shai SY, Vaughn C, Mohler J, Li Y, Song YH, Titterington J, Delafontaine P. IGF-I reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:2684–90. CrossRef PubMed
  60.  
  61. Johnsen SP, Hundborg HH, Sorensen HT, Orskov H, Tjonneland A, Overvad K, Jørgensen JO. Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke. J Clin Endocrinol Metab. 2005;90:5937–41. CrossRef PubMed
  62.  
  63. Tang JH, Ma LL, Yu TX, Zheng J, Zhang HJ, Liang Hm Shao P. Insulin-like growth factor-1 as a prognostic marker in patients with acute ischemic stroke. PLoS ONE. 2014;9:e99186. CrossRef PubMed PubMedCentral
  64.  
  65. Lioutas VA, Alfaro-Martinez F, Bedoya F, Chung CC, Pimentel DA, Novak V. Intranasal Insulin and InsulinLike Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke. Transl Stroke Res. 2015;6(4):264–75. CrossRef PubMed PubMedCentral
  66.  
  67. Clawson TF, Vannucci SJ, Wang GM, Seaman LB, Yang XL, Lee WH. Hypoxia-ischemia-induced apoptotic cell death correlates with IGF-I mRNA decrease in neonatal ratbrain. Biol Signals Recept. 1999;8(4-5):281–93. CrossRef PubMed
  68.  
  69. Fernandez AM, Garcia-Estrada J, Garcia-Segura LM, Torres-Aleman I. Insulin-like growth factor I modulates c-Fos induction and astrocytosis in response to neurotoxic insult. Neuroscience. 1997;76(1):117–22. CrossRef  
  70. Subramaniam S, Shahani N, Strelau J, Laliberte C, Brandt R, Kaplan D, Unsicker K. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway. J Neurosci. 2005;25:2838–52. CrossRef PubMed
  71.  
  72. Kooijman R. Regulation of apoptosis by insulin-like growth factor (IGF)- I. Cytokine Growth Factor Rev. 2006;17:305–23. CrossRef PubMed
  73.  
  74. Ribeiro M, Rosenstock TR, Oliveira AM, Oliveira CR, Rego AC. Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrialgeneration of reactive oxygen species in Huntington's disease knock-in striatal cells. Free Radic Biol Med. 2014;74:129–44. CrossRef PubMed
  75.  
  76. Puche JE, Castilla-Corta´zar I. Human conditions of insulin-like growth factor-I (IGF-I) deficiency. J Transl Med. 2012;10:1–29. CrossRef PubMed PubMedCentral
  77.  
  78. Kooijman R, Sarre S, Michotte Y, De Keyser J. InsulinLike Growth Factor I: A Potential Neuroprotective Compound for the Treatment of Acute Ischemic Stroke? Stroke. 2009;40:e83–8. CrossRef PubMed
  79.  
  80. Madathil SK, Saatman KE. IGF-1/IGF-R Signaling in Traumatic Brain Injury: Impact on Cell Survival, Neurogenesis, and Behavioral Outcome. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press. 2015, Chapter 7.
  81.  
  82. Wang J, Tang Y, Zhang W, Zhao H, Wang R, Yan Y, Xu L, Li P. Insulin-like growth factor-1 secreted by brain microvascular endothelial cells attenuates neuron injury upon ischemia. FEBS J. 2013;280:3658–68. CrossRef PubMed
  83.  
  84. Genis L, Davila D, Fernandez S, Pozo-Rodrigalvarez A, Martinez-Murillo R, Torres-Aleman I. Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury. F1000Research. 2014, 3. CrossRef  
  85. Dempsey RJ, Sailor KA, Bowen KK, Tureyen K, Vemuganti R. Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: Effect of exogenous IGF-1 and GDNF. J Neurochem. 2003;87:586–97. CrossRef PubMed
  86.  
  87. Chang HC, Yang YR, Wang PS, Kuo CH, Wang RY. The neuroprotective effects of intramuscular insulin-like growth factor-I treatment in brain ischemic rats. PLoS ONE. 2013;8:e64015. CrossRef PubMed PubMedCentral
  88.  
  89. Ruan L, Wang B, ZhuGe Q, Jin K. Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Res. 2015;1623:166–73. CrossRef PubMed PubMedCentral
  90.  
  91. Ruidavets JB, Luc G, Machez E, Genoux AL, Kee F, Arveiler D, Morange P, Woodside JV, Amouyel P, Evans A, Ducimetière P, Bingham A, Ferrières J, Perret B. Effects of insulin-like growth factor 1 in preventing acute coronary syndromes: The PRIME study. Atherosclerosis. 2011;218:464–9. CrossRef PubMed
  92.  
  93. Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, Stalla GK, Agha A. Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review. JAMA. 2007;298:1429–38. CrossRef PubMed
  94.  
  95. Aimaretti G, Ambrosio MR, Di Somma C, Fusco A, Cannavo S, Gasperi M, Scaroni C, De Marinis L, Benvenga S, Degli Uberti EC, Lombardi G, Mantero F, Martino E, Giordano G, Ghigo E. Traumatic brain injury and subarachnoid haemorrhage are conditions at high risk for hypopituitarism: Screening study at 3 months after the brain injury. Clin Endocrinol (Oxf ). 2004;61:320–6. CrossRef PubMed
  96.  
  97. Brandt L, Saveland H, Valdemarsson S, Sjoholma H, Reinsturp P. Fatigue after aneurysmal subarachnoid hemorrhage evaluated by pituitary function and 3D-CBF. Acta Neurol Scand. 2004;109:91–6. CrossRef PubMed
  98.  
  99. Tanriverdi F, Dagli AT, Karaca Z, Unluhirzarci K, Selcuklu A, Casanueva FF, Kelestimur F. High risk of pituitary dysfunction due to aneurysmal subarachnoid haemorrhage: A prospective investigation of anterior pituitary function in the acute phase and 12 months after the event. Clin Endocrinol (Oxf ). 2007;67:931–7. CrossRef PubMed
  100.  
  101. Kreitschmann-Andermahr I, Poll E, Hutter BO, Reineke A, Kristes S, Gilsbach JM, Saller B. Quality of life and psychiatric sequelae following aneurysmal subarachnoid haemorrhage: Does neuroendocrine dysfunction play a role? Clin Endocrinol (Oxf) . 2007;66:833-7. CrossRef PubMed
  102.  
  103. Cahill J, Calvert JW, Zhang JH. Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2006;26:1341–53. CrossRef PubMed
  104.  
  105. Bondanelli M, Ambrosio MR, Onofri A, Bergonzoni A, Lavezzi S, Zatelli MC, Valle D, Basaglia N, Degli Uberti EC. Predictive value of circulating insulin-like growth factor I levels in ischemic stroke outcome. J Clin Endocrinol Metab. 2006;91:3928–34. CrossRef PubMed
  106.  
  107. Visser-Meily JM, Rhebergen ML, Rinkel GJ, van Zandvoort MJ, Post MW. Long-term health-related quality of life after aneurysmal subarachnoid hemorrhage: relationship with psychological symptoms and personality characteristics. Stroke. 2009;40:1526–9. CrossRef PubMed
  108.  
  109. Baxter RC, Hawker FH, To C, Steward PM, Holman SR. Thirty-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients. Growth Horm IGF Res. 1998;8:455–63. CrossRef  

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