PATHOLOGICAL CHANGES DEVELOPMENT IN THE HEART WITH UNDERLYING CONVULSIVE SYNDROME MODEL OF VARIOUS ETIOLOGIES
N. Kolesova, L. Natrus, T. Bryuzhina, V. Lytvynenko, N. Suhareva S. Chukhrai
Research Institute of Experimental and Clinical Medicine of
O.O.Bogomolets National Medical University, Kyiv
DOI: https://doi.org/10.15407/fz62.04.023
Abstract
The basic mechanisms of myocardial damage were determined
experimentally in case of electroconvulsive (n = 30)
and corazole (n = 20) induced seizures in Wistar rats by
histochemical, pathological, electron microscopy and
biochemical methods.
It has been founded that pathological changes in the myocardium
underlying with electroconvulsive and corazole induced
seizures have unidirectional origin; nevertheless electroconvulsive
model has more intensity. It has been shown that structural
base of myocardial pathology development results in parallel
changes of microvessels and contractile myocardium with the
main focus on development of contractile changes of cardiomyocytes
and intramuscular capillaries spasm, which causes
blood flow impairment and reducing supply of oxygen to the
working cells. Structural changes in the myocardium develop
due to energy shifts which have been elucidated by confirmed
decrease SDG in cardiac activity (control 2,65+0,03 act. Units;
electroconvulsive model 2,15+0,02 act. Units; and corazole
model 2,25+0,02 act. Units), and increased - LDH (control
2,20+0,01 act. Units. electroconvulsive model 2,55+0,01 act.
Units; corazole model 2,45+0,01 act. Units.) histochemically,
showing evidence of hypoxia progression in the myocardium
tissue. It has been also shown processes of increasing degradation
as well as reducing synthesis of ATP biochemically(43%
electroconvulsive model and 41% corazole model). All this
results indicate the presence of hypoenergetics in case of electroconvulsive
and corazole experimental models of seizures.
The received results of complex researches allow considering
that adequate and rational treatment and prevention of seizures
(large and small epilepsy) requires anticonvulsants choose as
well as drug correction of the most affected parts of energy
metabolism via antihypoxants and antioxidants administration.
Keywords:
electroconvulsive and carozole convulsive syndromes; heart; metabolism; structure; pathogenesis.
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