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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(4): 18-22


Disorders of carbohydrate metabolism in experimental brain injury

S.V. Ziablitsev, S.V. Pishchulina, S.V. Kolesnikova, R.N. Boris, Ya.S. Yuzkiv

    Bogomolets National Medical University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz62.04.018

Abstract

In experimental heavy closed brain injury (mortality in five days – 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3- 3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic β-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury.

Keywords: brain injury; glucose; insulin; violations of carbohydrate metabolism.

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