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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(3): 48-53


I.G. Litovka1, V.Ya. Berezovskyi1, S.P. Veselskyi2, U.O. Zhernoklov1

  1. O.O.Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine;
  2. Petro Bogach Institute of Physiology of Kyiv National Taras Shevchenko University


We studied the impact of pharmacological doses (5 mg / kg) of melatonin on the parameters of bone remodeling in 3 month-old male Wistar rats in autumn and spring. In autumn experiments, introduction of melatonin to young rats caused an increase of alkaline phosphatase by 43,9% and hialuronidase activity by 15,4% and decreased the content of glycosaminoglycans by 46,7%. The concentration of total lipids and triglycerides was decreased. In spring, the introduction of melatonin to young rats inhibited the physiological remodeling of bone tissue, reduced the activity of alkaline phosphatase and increased the activity of acid on the 78% and tartrate resistant acid phosphatases by 72% regardless of the oxygen consumption level. The concentration of glycosaminoglycans and free amino acids increased. Such changes may disturb the integrity of the organic matrix and reduce the fixation of inorganic component of connective tissue – hydroxyapatite crystals.

Keywords: melatonin, bone tissue.


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