Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(2): 57-63


T.I. Stanishevskaya, I.P. Anosov

    Bogdan Khmelnitsky Melitopol State Pedagogical University


In experiments on white rats the character of effect of experimental hyperthyroidism was studied on the skeletal muscle (m. tibialis anterior) of white rats. It is shown that at experimental hyperthyroidism (rectal temperature of 38,5±0,10С) a muscle acquires high functional capabilities. It is shown that the latent period of generation and the time of development of positive wave “М-respones” are (-32%) and (- 22%). The latent period of shortening of muscle diminishes (- 23%) at single contraction. During experimental thyrotoxicosis (rectal temperature of 39,4±0,2 0 С) we observed physiopathological changes in the functional state of skeletal muscle: the lengthening of the latent period of generation of “М-respones” (+21%), an increase in the time of development of positive wave (+54%) and of latent period of shortening of muscle (+14%). It is concluded that in experimental hyperthyroidism and thyrotoxicosis the functional state of skeletal muscle changed in different directions.

Keywords: thyroid hormones; skeletal muscle; “М-respones”; the latent period of muscle contraction.


  1. Sobolev VI, Trush VV, Litvyak KA, Morozova IN. Frequency Dependence of Parameters of the М Response of the Rat M. Tibialis in the Norm and in Experimental Hyperthyroidism and Hypercorticoidism. Neurophysiology. 2015; 47(1):53-60. CrossRef  
  2. Stanishevskaya TI, Sobolev VI. Characterization of the latent period of excitation and shortening of anterior tibial muscle of white rats depending on the blood level of thriiodothyronine. Fiziol Zh. 2012; 58(1):68-75. [Ukrainian]. CrossRef
  3.  Rodinskiy OG, Guz VA, Guz LV. Overview of efferent brand excitability of spinal reflex arcs under conditions of model hyperthyroidism. Fiziol Zh. 2010; 56(2):48-9. [Ukrainian]. CrossRef  
  4. Connelly TJ, Hayek R, Ukhareva SM. L-thyroxine activates the intracellular Ca2+ release channel of skeletal muscle sarcoplasmic reticulum. Biochem Mol Biol Int. 1994; 32(3):441-8. PubMed
  6. Harrison AP, Clausen T. Thyroid hormone-induced upregulation of Na+ channels and Na+-K+ pumps: implications for contractility. Am J Physiol. 1998; 274(5):864-R867.
  8. Nerush PA, Makii EA, Rodinsky AG. Age features of functioning of nervous - muscular system of rats in conditions hyperthyroidism. Fiziol Zh. 2001; 47(5):12-7[Ukrainian] CrossRef PubMed
  10. Rodynskyi OG. Analysis of activity of cholinergic receptors in skeletal muscle conditions of experimental hyperthyroidism. Odessa Med J. 2001; 68(6):33-5. [Ukrainian].
  12. Sobolev VI, Moskalets TV. Influence of experimental athyreosis on energy isometric contraction of the muscles of white rats (reaceach of in situ). Fiziol Zh. 2007; 53(5):86-90. [Ukrainian]. CrossRef
  13. Kmetko IL, Sobolev VI. Characteristic performance of skeletal muscle of white rats during development of experimental hyper- and thyrotoxicosis (research in situ). Bull Exp Biol Med. 2012; 94(3):236-40. [Ukrainian].
  15. Sobolev VI, Makhsudov MS, Merkhelevich LG, Rabo Hemedo, Dakoshta M Influence of 2,4-dinitrophenol on the temperature effect of muscle contraction in experimental hyperthyroidism. I.M. Sechenov Physiol J. 1995; 81(3): 80-4. [Russian].
  17. Stanishevskaya TI. The dependence of thermal cost of muscular contraction of white rats from level of circulatory triiodothyronine after highest limit of physiological norme. Bull Exp Biol Med. 2012; 1(94):247-52. [Ukrainian].
  18. Gecht B.M. Theoretical and clinical electromyography. Leningrad: Science; 1990. [Russian].
  20. Halbert AJ. Thyroid hormones and their effects: a new perspective. Biol rev Cambridge Phil Soc. 2000; 75(4):519-631. CrossRef  
  21. Valdina EA. Thyroid disease. SPb.: Peter; 2006. [Russian]. Marzoev A.Y., Rubezhov B.V., Klebanov G.Y. Thyroxin action on the function of skeletal muscle sarcoplasmic reticulum. Bull Exp Biol Med. 1980; 5:541-2. [Russian].
  23. BrodieC, Sampson SR.Characterization of thyroid hormone effects on Na-K pump and membrane potential of cultured rat skeletal myotubes. Endocrinology. 1988; 2:891-7. CrossRef PubMed
  25. Harris DR, Green WL, Craelius W. Acute thyroid hormone promotes slow inactivation of sodium current in neonatal cardiac myocytes. Biochem Biophys Acta. 1991; 1095(2):175-1. CrossRef  
  26. Brodie C, Sampson SR. Characterization of thyroid hormone effects on Na+ channel synthesis in cultured skeletal myotubes: role of Ca2+ myotubes. Endocrinology. 1989; 2:842-9. CrossRef PubMed
  28. Davis PJ, Davis FB, Lawrence WD. Thyroid hormone regulation of membrane Ca2+-ATPase activity. Endocr Res. 1989; 15:651-82. CrossRef PubMed
  30. Valiullin VV. Neurotrophic control of skeletal muscle in hyperthyroid animals. Questions of Neurobiology (scientific papers). Kazan. 1987; 68:48-53. [Russian].
  32. Rodynskyi OG. Mechanisms of functioning of the components of spinal reflex arcs under the conditions of hyperthyrosinemia. Med Perspective. 2009; 14(2):8-17. [Ukrainian].

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.