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Replacing effects of exogenous histamine, serotoninand heparin on leukocytic reaction in inflammation
N.A. Klimenko, G.yU.pyshnov
Kharkov State Medical University, Ministry ofPublic Health of the Ukraine
Abstract
On the model of E.coli - induced acute infectious
peritonitis in rats previously depleted on mast cells of
peritoneal cavity the replacing effects of various doses
of exogenous histamine, serotonin and heparin and
their complex on leukocytic reaction of inflammatory
focus and blood were studied. In was shown that all
of the used substances had a meaning in the mechanisms
of modulating effect of mast cells on leukocytes.
The analogous on direction to mast cells` ones effects
on leukocytes were produced mostly by histamine and
especially by the complex of substances.
References
- СПИСОК ЛІТЕРАТУРИ
- Дыгай А.М., Клименко Н.А. Воспаление и гемо-поэз. - Томск: Изд-во Томск. ун-та, 1992. - 276 с.
- Клименко Н.А. Взаимодействие тучных клеток слейкоцитами в повышении проницаемости сосу-дов очага воспаления // Бюл. эксперим. био-логии и медицины. - 1992. - 113, N 1. - С. 28-30.
- Клименко Н.А., Дыгай А.М., Абрамова Е.В. идр. Роль тучных клеток в реакциях систем кро- ви при воспалении //Там же. - 1991. - 112, N 9. -С. 305-307.
- Kлименко М.О., Пишнов Г.Ю. Роль тучних клi-тин в iнфiльтративних явищих при запаленнi //Фiзiол. журн. - 1997. - 43, N 3-4. - С. 33-39.
- Лабораторные методы исследования в клинике: / Под ред. В.В. Меньшикова. - М.:Медицина, 1987. - 368 с.
- Липшиц Р.У., Клименко Н.А. Освобождение ги-стамина и серотонина и проницаемость сосудовв очаге острого асептического воспаления //Бюл. эксперим. биологии и медицины. - 1977. -84, N 12. - С. 660-664.
- Шубич М.Г., Медникова В.Г. NBT-тест у детей внорме и при гнойно-бактериальных инфекциях// Лаб. дело. - 1978. - N 9. - С. 515-518.
- Berliner S., Fishelsоn Z., Wasserman L. et al.Synergism between zymosan-activated serum andheparin in the induction of polymorphonuclearleukocyte aggregation // Biomed. Pharmacother.1988. - 42. - P. 69-72.
- 9. Casale T.B., Wescott S., Rodbard D., Kaliner M.Characterization of histamine H-1 receptors onhuman mononuclear cells // Int. J. Immuno-pharmac. - 1985. - 7. - P. 639-645.
- 10. Diaz P., Jones D.G., Kay A.B. Histamine receptoron guinea - pig alveolar macrophages: chemicalspecificity and the effect of H1- and H2-receptoragonists and antagonists // Clin. Exp. Immunol. -1979. - 70. - P. 82-87.
- Mannaioni P.F., Fantozzi R., Giannella E., MasiniE. Pathophysi- ological significance of the distri-bution of histamine recceptor sub-types: a proposeddual role for histamine in inflammation and typeI hypersensitivity reactions // Agents Actions. -1988. - 24. - P. 26-34.
- Paegelow I., Werner H. Acute inflammation, infla-mmatory media- tors and mononuclear cell reaction// Wiss. Beitr. M. Luther - Univ. Halle-Witten-berg. - 1987.- N 100. - P.114-123.
- Redini F., Tixer J.-M., Petitou M. et al. Inhibitionof leukocyte elastase by heparin and its derivatives// Biochem. J. 1988. - 252. - P. 515-519.
- Seligmann B.E., Fletcher M.P., Gallin J.I. Hista-mine modulation of human neutrophil oxidativemetabolism, locomotion, degranula- tion, and mem-brane potential changes // J. Immunol. 1983. -130. - P. 1902-1909.
- Spisani S. Interaction between neutrophils andmediftors of inflammation // Adv. Exp. Med.Biol. - 1982. - 141. - P. 29-37.
- Van Epps D.E., Kutvirt S.G., Potter J.W. In vitro effects of cetirizine and histamine on human neutro-phil function // Ann. Allergy. - 1987. - 59. - P. 13-19.
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