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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(4): 19-24


Replacing effects of exogenous histamine, serotoninand heparin on leukocytic reaction in inflammation

N.A. Klimenko, G.yU.pyshnov

    Kharkov State Medical University, Ministry ofPublic Health of the Ukraine


Abstract

On the model of E.coli - induced acute infectious peritonitis in rats previously depleted on mast cells of peritoneal cavity the replacing effects of various doses of exogenous histamine, serotonin and heparin and their complex on leukocytic reaction of inflammatory focus and blood were studied. In was shown that all of the used substances had a meaning in the mechanisms of modulating effect of mast cells on leukocytes. The analogous on direction to mast cells` ones effects on leukocytes were produced mostly by histamine and especially by the complex of substances.

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