ORGANISM REACTION TO DOSED HYPOXIC HYPOXIA IN THE HEALTHY SUBJECTS AND INDIVIDUALS WITH PREDIABETIC HYDROGEN METABOLISM DISTURBANCES
O.V. Korkushko, V.B. Shatilo, V.P. Chyzhova, S.S. Naskalova, Ye.D. Osmak, A.V. Gremiakov, I.A. Antoniuk-Scheglova, G.V. Gavalko, N.S. Naumchuk
D.F. Chebotarev Institute of Gerontology AMS Ukraine, Kyiv
o assess organism reaction to dosed hypoxic hypoxia in the
human invividuals with pre-diabetic hydrogen metabolism
disturbances.Altogether 40 subjects, age range 50-74 years,
were examined, including 18 persons with pre-diabetic hydrogen
metabolism disturbances and 22 essentially healthy
subjects. All of them underwent dosed hypoxic test (breathing
gas mixture containing 12 % of oxygen during nearly 20 min.
The following monitorings were performed: blood saturation
(SpO2), breathing rate, arterial blood pressure and heart rate;
and standard glucose tolerance test (GTT) for blood plasma
glucose and insulin concentration. The patients with prediabetic
hydrogen metabolism disturbances displayed a more
significant decrease of SpO2 and less effective functioning
of the respiratory and cardiovascular systems during dosed
hypoxic test compared with the healthy individuals without
hydrogen metabolism disturbances. After redistribution of
study subjects relative the degree of SpO2 decrease at dosed
hypoxic test in the subgroup with satisfactory resistance to
hypoxia (subgroup 1: SpO2 more than 80 %) and with reduced
(subgroup 2: SpO2 80 % or less) we have found that the fasting
glucose level after 2-hour GTT was significantly higher in
subgroup 2 versus subgroup 1. The obtained results indicate
the interrelationship between organism reaction to hypoxia,
in particular between the degree of arterial hypoxemia during
performance of the dosed hypoxic test and the indices of fasting
glycemia and at standard GTT. The patients with pre-diabetic
hydrogen metabolism disturbances are characterized with
lower resistance to hypoxic hypoxia.
pre-diabetic hydrogen metabolism disturbances; glucose tolerance test; insulin resistance; hypoxia.
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