Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(6): 129-138

PHYSIOLOGY AND PHARMACOLOGICAL PROPERTIES OF NANOMATERIALS

I.S. Chekman

    Bogomolets National Medical University, Kyiv
DOI: https://doi.org/10.15407/fz61.06.129


Abstract

Literature data and results of our department studies on theoretical and practical basics of nanoscience were summarized in the article. Much attention is paid to research in the field of physical, chemical, biological, medical, physiological, pharmacological, and toxicological properties of nanomaterials with the aim of their wider implementation into practice lately. The discovery of new quantum/wave properties of nanoparticles is of particular importance. The author of the article advances an idea: wave properties of nanomaterials play greater role with a decrease in particle size. The preponderance of wave properties compared with corpuscular ones in nanostructures determines a great change in their physicalchemical properties and an increase in physical, mechanical, biological, physiological, pharmacological, and toxicological activity. The idea advanced in the article hasn’t been verified by theoretical or experimental studies for now. Joined efforts of scientists of different scientific fields are needed. A confirmation of hypothesis by specific findings will be of great importance for physiology, medicine, pharmacology and promote an implementation of new efficacious preparations into clinical practice. New fundamental discoveries could be made only by multidisciplinary approach.

Keywords: nanoscience; nanomaterials; wave properties; quantum physics; quantum mechanics; nanopharmacology.

Full text: (PDF, in Ukrainian)

References

  1. Horbyk, P. P., Horobets, S. V., Turelyk, M. P., Chekhun, V. F., & Shpak, A. P. Bіofunktsionalіzatsіa nanomaterіalіv i nanokompozytіv [The biofunctionalization of nanomaterials and nanocomposites]. 2011, Kyiv: Naukova Dumka.
    2.  
  2. Rahulia, A. V., & Skorokhod, V. V. Konsolidirovannie nanostrukturnie materialy [Consolidated nanostructured materials]. 2007, Kyiv: Naukova Dumka.
    3.  
  3. Di Ventra, M., Evoy, S., & Heflin, R. Introduction to nanoscale science and technology. (2004). New York: Springer.
    4.  
  4. Shaefer, H. E.. Nanoscience. The science of the small in physics, engineering, chemistry, biology and medicine. 2010, Berlin, Heidelberg: Springer.
    5.  
  5. Chekman, I. S., & Simonov, P. V. Pryrodni nanostruktury ta nanomekhanizmy [Natural nanostructures and nanomechanisms]. 2011, Kyiv: Zadruha.
    6.  
  6. Chekman, I. S. & Simonov, P. V. Structure and function of biological membranes: the impact of nanoparticles. 2012, International Physiology and Pathophysiology, 3(2), 187-208.
    7.  
  7. Chekman, I. S., Tarasova K. V., Shevchuk V. H. Physiological properties and possible correction of adenosine triphosphate-sensitive potassium channel function. 2008, Fiziol Zh., 54(1), 94-107.
    8.  
  8. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. Molecular biology of the cell (5th ed.). 2008, New York: Garland Publishing.
    9.  
  9. Helms, J. B., & Zurzolo, C. Lipids as targeting signals: lipid rafts and intracellular trafficking. 2004, Traffic, 5(4), 247-54.
    10.  
  10. Simons, K., & Gerl, M. J. Revitalizing membrane rafts: new tools and insights. Nature reviews. Molecular cell biology. 2010. 11(10), 688-99.
    11.  
  11. Krishnamurthy, V., Monfared, S., & Cornell, B. Ion channel biosensors – part I: construction, operation, and clinical studies. 2010. IEEE Transactions on Nanotechnology, 9(3), 313-22.
    12.  
  12. Bocquet, L., & Charlaix, E. Nanofluidics, from bulk to interfaces. 2010. Chemical Society Reviews, 39(3), 1073-95.
    13.  
  13. Schliwa, M., & Woehlke, G. Molecular motors. 2003. Nature, 422(6933), 759-65.
    14.  
  14. Chiancone, E., Ceci, P., Ilari, A., Ribacchi, F., & Stefanini, S. Iron and proteins for iron storage and detoxification. 2004. Biometals, 17(3), 197-202.
    15.  
  15. Strbak, O., Kopcansky, P., & Frollo, I. Biogenic magnetite in humans and new magnetic resonance hazard questions. 2011. Measurement Science Review, 11(3), 85-91.
    16.  
  16. Tesch, W., Eidelman, N., Roschger, P., Goldenberg, F., Klaushofer, K., & Fratzl, P. Graded microstructure and mechanical properties of human crown dentin. 2001. Calcified Tissue International, 69(3), 147-57.
    17.  
  17. Vallet-Regi, M., & Ruiz-Hernandez E. Biomimetics: nanoceramics from bone regeneration to cancer nanomedicine. 2008. Adv. Mater. 23(44), 5177-218.
    18.  
  18. Roiter, Y., Ornatska, M., Rammohan, A. R., Balakrishnan, J. Heine, D. R., & Minko S. Interaction of lipid membrane with nanostructured surfaces. 2009. Langmuir, 25(11), 6287-99.
    19.  
  19. Azam, A., Ahmed, A. S., Oves, M., Khan, M. S., & Memic. A. Size-dependent antimicrobial properties of CuO nanoparticles against Gram-positive and -negative bacterial strains. 2012. Internat. Nanomedicine, 7, 3527-35.
    20.  
  20. Hirn, S., Semmler-Behnke, M., Schleh, C., Wenk, A., Lipka, J., Schäffler, M., Takenaka, S., Möller, W., Schmid, G., Simon, U., & Kreyling, W. G. Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration. 2011. Eur J Pharmacol and Biopharmaceut. 77(2), 407-16.
    21.  
  21. Ivask, A., Kurvet, I., Kasemets, K., Blinova, I., Aruoja, V., Suppi, S., Vija, H., Käkinen, A., Titma, T., Heinlaan, M., Visnapuu, M., Koller, D., Kisand, V., & Kahru, A. Size-dependent toxicity of silver nanoparticles to bacteria, yeast, algae, crustaceans and mammalian cells in vitro. 2014. PLoS One, 9(7), e102108.
    22.  
  22. Vakarchuk, I. O. 2012. Kvantova mekhanika [Quantum mechanics]. Lviv: Ivan Franko National University of Lviv.
    23.  
  23. Landau, L. D., & Lifshyts, E. M. Kvantovaia mekhanika. Nereliativisticheskaya teoria. Teoreticheskaia fizika [Quantum mechanics. Non-relativistic theory. Theoretical physics]. 2008. Moskva: Fizmatlit.
    24.  
  24. Hoking, S. Kratkaia istoria vselennoi [A brief history of time] (translated from English). 2010. Saint Petersburg: Amfora.
    25.  
  25. Thompson, D. Michael Faraday' s recognition of ruby gold: the birth of modern nanotechnology. His 1857 lecture to the royal society in London. Gold Bulletin. 2007. 40(4), 267-69.
    26.  
  26. Poplavko, Yu. M., Borysov, O. V., & Yakymenko, O. I. Nanofizyka, nanomaterialy, nanoelektronika [Nanophysics, nanomaterials, Nanoelectronics]. 2012. Kyiv: NTUU KPI.
    27.  
  27. Shirinian, A. S., & Makara, V. A. Current problems of nanomaterials and nanotechnology. Nanosystemy, Nanomaterialy, Nanotekhnologii, 2010. 8(2), 223-69.
    28.  
  28. Demikhovski, V. Ya., & Vugalter, G. A. Fizika kvantovyh nizkorozmernikh struktur [The physics of quantum lowdimensional structures]. 2000. Moscow: Lotos.
    29.  
  29. Yekimov, A. I., & Onushchenko, A. A. A quantumdimentional effect in three-dimentional semiconductor microcrystal's. Pisma v ZETF, 1981. 34, 363-66.
    30.  
  30. Liulman, B., & Liulman, A. Kvantovaia biokhimia [Quantum biochemistry]. 1965). Moscow: Mir.
    31.  
  31. Chekman, I. S. Kvantova farmakologia [Quantum pharmacology]. 2012). Kyiv: Naukova Dumka.
    32.  
  32. Minaev, B. P. On electron mechanisms of molecular oxygen activation, Ukrainskii Biokhimicheskii Zhurnal, 2009. 81(3), 3-28.
    33.  
  33. Chekman, I. S., Minaev, B. P., & Nebesna, T. Yu. A synthesis of a new type of silver and gold nanoparticles with the use of synthetic humic compounds (a literature and personal study review). Zhurnal NAMN Ukrainy, 2013. 18(4), 451-60.
    34.  
  34. Ziese, M., & Thornton, M. J. Spin electronics; lecture notes in physics. 2001. Berlin: Springer.
    35.  
  35. Uvarova, I. V., Horbik, P. P., Horobets, S. V., Ivashchenko, O. A., & Ulianchych, N. V. Nanomaterialy medychnoho pryznachnnia [Nanomaterials for medical application]. 2014. Kyiv: Naukova Dumka.
    36.  
  36. Chekman, I. S., Ulberh, Z. R., Malanchuk, V. O., Horchakova, N. O., & Zupanets, I. A. Nanonauka, nanobiologia, nanofarmatsia [Nanoscience, nanobiology, nanopharmacy]. 2012. Kyiv: Poligraf Plus.
    37.  
  37. Abramov, N. V., Bagatskaia, A. N., & Beliakova, L. A. Nanomaterialy i nanokompozity v meditsyne, biologii, ekologii [Nanomaterials and nanocomposites in medicine, biology, ecology]. 2011. Kyiv: Naukova Dumka.
    38.  
  38. Chandra Sekhar, M., Rao, M. N., Prasad, B. V. K., & Suryanarayana, S. V. Vitality of physics in nanoscience and nanotechnology. IOSR J. App. Physics, 2015. 7(1), 1-5.
    39.  
  39. Klabunde, K. J. Nanoscale materials in chemistry. 2001. New York: John Wiley & Sons.
    40.  
  40. Qu, L., Dai, L., Stone, M., Xia, Z., & Wang, Z. L. Carbon nanotube arrays with strong shear binding-on and easy normal lifting-off. Science, 2008. 322(5899), 238-42.
    41.  
  41. Roduner, E. Nanoscopic materials: size-dependent phenomena. 2006. Cambridge: RSC Publishing.
    42.  
  42. Pohrebniak, A. D., Shpak, A. P., Azarenkov, N. A., & Beresnev, V. M. The structure and properties of hard and superhard nanocomposite coatings. Uspekhi Fizicheskikh Nauk, 2009. 179(1), 35-64.
    43.  
  43. Oleinikov, V. A. Quantum dots – nanosized sensors for medicine and biology. Priroda, 2010. (3), 22-28.
    44.  
  44. Paton, B. E., Moskalenko, V. F., Movchan, B. O., & Chekman, I. S. Nanoscience and nanotechnology: technical, medical and social aspects. Visnyk NAN Ukrainy, 2009 (6), 18-26.
    45.  
  45. Chekman, I. S. Nanofarmakologia [Nanopharmacology]. 2011. Kyiv: Zadruha.
    46.  
  46. Chekman, I. S. Wave properties of nanoparticles: the view of a problem. Likarska Sprava, 2013. 7, 3-8.
    47.  
  47. Chuiko, A. A., Pohorelyi, V. K., & Pentiuk, A. A. Maditsinskaia khimia i klinicheskoe primenemie dioksida kremnia [Medical chemistry and clinical application of silica dioxide]. 2003. Kyiv: Naukova Dumka.
    48.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.