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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(6): 53-59

TISSUE BLOOD FLOW IN THE DIGESTIVE ORGANS OF RATS WITH ACUTE PANCREATITIS AFTER CORVITIN ADMINISTRATION

T.V. Vovkun1, P.I. Yanchuk1, L.Y. Shtanova1, A.S. Shalamaу2

  1. Kyiv Taras Shevchenko National University
  2. Closed Joint Stock Company “Borschagovsky ChemicalPharmaceutical Plant “, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz61.06.053


Abstract

We have investigated the action of quercetin (in a modified form – Corvitin, ВСРР, Ukrainе) on the rate of blood flow in the pancreas, liver and gastric mucosa of rats with acute pancreatitis (АР) caused by administration of L-arginine. The rate of blood flow was measured by hydrogen clearance method with electrochemical his generation using Polarographs Lr-9 (Czech Republic). During the first 10 days after modelling of АР in these organs it was observed a gradual decrease compared to the intact animals in the rate of blood flow by 42% (P<0,01) in the pancreas, by 61% (P<0,001) in the liver and by 64% (P<0,001) in the gastric mucosa, i.e., the most significant changes occurred in the gastric mucosa, the least – in the tissue of the pancreas. Compared with the control group of animals with modelling acute pancreatitis which during 20 days was administered only saline, application of Corvitin (5 mg/kg, 1 time per day from 11 to 20 days of experiment) in varying degrees promoted to the recovery of the rate of blood flow in all investigated organs: in the pancreas – fully, in the liver – almost entirely and in the gastric mucosa – only partially. Thus, based on obtained results Corvitin can be recommended for partial or complete correction of blood flow disturbances, which arise in the pancreas and other organs of the digestive system in AP. Corvitin can improve the functional state of these organs in the early stages of the disease and accelerate the full restoration of their functions.

Keywords: L-arginine; acute pancreatitis; pancreas; liver; gastric mucosa; Corvitin; rate of blood flow.

Full text: (PDF, in Ukrainian)

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