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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(6): 46-52


Ye.P. Man’kovskaya1, A.V. Maznychenko1, N.O. Pil’kevych1, V.O. Maisky1, O.V. Vlasenko2, O.V. Dovgan’2

  1. O.O. Bogomoletz Institute of Physiology, NAS of Ukraine, Kyiv;
  2. Pirogov National Medical University, MPH of Ukraine, Vinnitsa


The aim of this research was to reveal the changes in the NADPH-d reactivity in the lumbal spinal cord (L6/L7) of cats with unilateral acute myositis of the mm. gastrocnemiussoleusafter intramuscular injections of carrageenan. The effect of unilateral muscle inflammation was expressed in a significant increase in the number of NADPH-d-reactive neurons in ipsilateral and contralateral intermediate (lamina VII; 17,62 ± 2,7 and 20,67 ± 3,3) and medial (lamina VIII; 7,3 ± 1,9 and 6,0 ± 2,1 respectively)zones of the ventral horns. However, a clear decline of the reactive cells was recorded on the ipsilateral side within the area around the central canal (lamina X). An increase in the NADPH-d reactivity within the ventral horns on both sides on the spinal cord and the induction of such reactivity (contralaterally) in large multipolar neurons localized in the dorsal part of the intermediate zone were revealed in cats with unilateral acute muscle inflammation. It is hypothesized, that during acute myositis, plastic changes in different layers of the dorsaland ventral horns activate the processes of disinhibition due to an increase in the number of NOS-containing/NADPHd-reactive neurons in the spinal gray matter.

Keywords: spinal cord; NADPH-d-reactive neurons; muscle inflammation; carrageenan; cats.


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