FUNCTIONING PROTEASES IN THE ESOPHAGUS MUCOSA AFTER CHEMICAL BURNS
T.V. Ishchuk, O.M Savchuk, Ya.B. Raetska, V.V. Vereschaka, L.I. Ostapchenko
Educational and Scientific Centre «Institute of Biology», Taras Shevchenko National University of Kyiv
The main result of esophagus burn is the formation of scars,
that caused by excessive synthesis of collagen and changes
the balance of metalloproteinases and their tissue inhibitors.
It was studied the activity of proteolytic enzymes, participation
of MMP (metalloproteinase) and their tissue inhibitors (TIMP)
in alkali burns of the esophagus 1st and 2nd degrees. We have
shown a significant increase of TIMP level in homogenate
after alkali burns of the esophagus (an average of 31-56%
depend on of burn degree). We observed a reduced activity
of serine proteinase after 1st degree burns on 15th, 21st day 35
and 18% respectively, after burns 2nd degree on 15th, 21st day
54 and 50%. The decrease of activity MMP after 1st degree
burns on 15th and 21st day 30, 19%, respectively, in conditions
of chemical burns 2nd degree on 15th and 21st day 30, 37%.
These data may indicate the development of scarring after
burn simulation of 2nd degree. Further investigation of the
MMP and TIMP in the process of wound healing can be useful
in creating effective approaches to prevent formation of post
scarring of the esophagus.
caustic burns of the esophagus; matrix metalloproteinases; tissue inhibitor of metalloproteinases.
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