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Reparative processes in jaw bones under using of different plastic materials
Kh. R. Pohranychna
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz62.06.110
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Abstract
The comparative experimental study of osseous tissue regeneration in the created foraminous mandibular
defects being implanted with bioceramics Kergap T-300 and osteoplastic material Osteopor, as well as
justifying the possibility of using the developed reparative material in the maxillofacial surgery clinics based
on the analysis of histomorphological research results for are the paper objectives. 78 nonlinear white male
rats weighing 240-300 g with foraminous mandibular defects were used as models for studying impact on the
reparative osteogenesis processes made by the bonegraft material. Reparative changes in the implantation
sites were studied in real time with the help of histological drugs under the optical microscopy. The graft
components were the morphometry object calculated at the percentage ratio per the graft space unit in three
cuts from each section. In 27.7% cases the rats’ mandibular defects repair under the natural environment
conditions of osseous tissue regeneration achieved with a blood clot was complicated by purulence, the
surgical wound dehiscence with pyorrhea or perimandibular abscess. In other cases regeneration caused
the development of heterogeneous graft made of chondroid-fibroblastic and osteoid tissues of different
organization levels. The comparative experimental morphological and histomorphometric studies of the
bone regeneration involving the replacement of created jaw defects with osteoplastic material Kergap-T
alone and in the combination with the lyophilized biological placenta implant Osteopor proved that the
latter speeded up the beginning of active regenerative processes promoting the early defect filling with the
neogenic organotypic osseous tissue comprising 52(43-63)[46-58]% and 74(57-85)[64-79]% of the bone
graft in 60 and 90 days after the surgical intervention correspondingly (being equal to 24(13-29)[20-28]%
і 32(27-38)[30-34]% correspondingly in cases when Kergap-T was applied. According to the morphometric
research findings, in cases of Osteopor and Kergap-T application the tabular bone element of the graft was
equal to 53 (43-60) [46-56]% and 15(13-18) [14-16]% correspondingly.
Keywords:
reparative osteogenesis; placenta tissue; bone grafting materials.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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