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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(6): 110-117

Reparative processes in jaw bones under using of different plastic materials

Kh. R. Pohranychna

    Danylo Halytsky Lviv National Medical University, Lviv, Ukraine


The comparative experimental study of osseous tissue regeneration in the created foraminous mandibular defects being implanted with bioceramics Kergap T-300 and osteoplastic material Osteopor, as well as justifying the possibility of using the developed reparative material in the maxillofacial surgery clinics based on the analysis of histomorphological research results for are the paper objectives. 78 nonlinear white male rats weighing 240-300 g with foraminous mandibular defects were used as models for studying impact on the reparative osteogenesis processes made by the bonegraft material. Reparative changes in the implantation sites were studied in real time with the help of histological drugs under the optical microscopy. The graft components were the morphometry object calculated at the percentage ratio per the graft space unit in three cuts from each section. In 27.7% cases the rats’ mandibular defects repair under the natural environment conditions of osseous tissue regeneration achieved with a blood clot was complicated by purulence, the surgical wound dehiscence with pyorrhea or perimandibular abscess. In other cases regeneration caused the development of heterogeneous graft made of chondroid-fibroblastic and osteoid tissues of different organization levels. The comparative experimental morphological and histomorphometric studies of the bone regeneration involving the replacement of created jaw defects with osteoplastic material Kergap-T alone and in the combination with the lyophilized biological placenta implant Osteopor proved that the latter speeded up the beginning of active regenerative processes promoting the early defect filling with the neogenic organotypic osseous tissue comprising 52(43-63)[46-58]% and 74(57-85)[64-79]% of the bone graft in 60 and 90 days after the surgical intervention correspondingly (being equal to 24(13-29)[20-28]% і 32(27-38)[30-34]% correspondingly in cases when Kergap-T was applied. According to the morphometric research findings, in cases of Osteopor and Kergap-T application the tabular bone element of the graft was equal to 53 (43-60) [46-56]% and 15(13-18) [14-16]% correspondingly.

Keywords: reparative osteogenesis; placenta tissue; bone grafting materials.


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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.