Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(6): 95-101

THE STUDY OF THE RELATIONSHIP BETWEEN THE ACTIVITY OF EPIPHYSIS AND GONADS IN MALE RATS IN DIFFERENT SEASONS

V. Hnatiuk, N. Kononenko

    National University of Pharmacy, Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz62.06.095


Abstract

In male rats of different ages, we studied the functional activity of the pineal gland and the gonads during different seasons by determining the levels of melatonin and testosterone in the blood serum. It was found that the highest levels of melatonin observed in male rats in summer and winter, and the lowest – in autumn. The lowest level of melatonin has been established in the group of rats aged 9 months – 127.28+5.11 pmol/l that was 22% lower than the level of melatonin in 3 months old rats (P≤0,05), and 20% below the level of melatonin in rats of 15 months old (P≤0,05). The highest level determined in rats aged 3 months (corresponds to the age of man –14 years old), the lowest – in rats 20 months (corresponds to the age 55-56 years old). At the same time, the low level of melatonin was defined in rats aged 9 months in the autumn (corresponds to the age of man 29-30 years). In the study of testosterone levels in different seasons it was found that the highest level in all age groups presents in autumn, the lowest – in winter. When comparing the levels of testosterone in different age groups, it was determined that the fall of the highest level of testosterone present in the blood of males age 9 months and 15 months, which corresponds to the age of 29-30 and 43-44 of human years. Significant difference between the levels of testosterone in the groups that correspond to the reproductive age – rats of age 3, 9 and 15 months, are present only in the autumn; spring and summer – significant differences between the levels of testosterone absent. The degree of correlation differed in rats of different ages in different seasons: the highest correlation between the levels of melatonin and testosterone was determined in rats aged 9 months in autumn. The correlation coefficients in rats aged 20 months old have been weak - from 0.05 in the spring to 0.17 in autumn that shows the changes in neurohormonal regulation which occur with age.

Keywords: epiphysis; gonads; melatonin; testosterone; seasons; sex; age.

Full text: (PDF, in Ukrainian)

References

  1. Korkushko OV, Shatilo VB. Functional status pineal gland of the brain with aging: ways of correction desynchronosis. Bukovin Med Visnik. 2006;4(10):8–10. [Ukrainian].
    2.  
  2. Komarov FI, Rapoport SI, Malinovskaia NK, Anisimov VN. Melatonin in health and disease. Moscow; 2004.[Russian].
    3.  
  3. Anisimov VN. Chronometer of life. Priroda. 2007;7:3–10. [Russian].
    4.  
  4. Yanko RV. Morphofunctional state of the thyroid gland after exposure to melatonin. Fiziol Zh. 2015;5(61):47–51. [Ukrainian].
    5.  
  5. Kaladze NN, Soboleva EM, Skoromnaia NN. Results and prospects of physiological, pathogenetic and pharmacological effects of melatonin. Zdorov Reb. 2010; 2(32):156–66. [Russian].
    6.  
  6. Minukhin AS. The role of androgens in the provision of sexual function in men. Probl Endocr Path. 2010; 1:99–106. [Russian].
    7.  
  7. Minukhin AS, Bondarenko VA. The role of hormonal factors in the regulation and maintenance of sexual function of men. Probl Endocr Path. 2011; 1:76–82. [Russian].
    8.  
  8. Kostenko E, Manevich TM, Razumov NA. Desynchronosis as One of the Most Important Factors of Cerebrovascular Disease. Lecheb Delo. 2013; 2:104–116. [Russian].
    9.  
  9. Osnovni prichini visokogo rivnya smertnosti v Ukrayini. News Med and Pharm. 2010; 22 (350):URL: http:// www.mif-ua.com/archive/article/15170. (Accessed 01.04.2016). [Russian].
    10.  
  10. Brambilla DJ, Matsumoto AM, Araujo AB, McKinlay JB. The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J Clin Endocrinol Metab. 2009; 94(3):907–13. CrossRef PubMed PubMedCentral
    11.  
  11. Korkushko OV, Khavinson VKh, Shatilo VB, Pisaruk AV, Labunets IF. Diurnal rhythms of changes in the function of cardiovascular system and its autonomic regulation in apparently healthy elderly subjects with special reference to the state of melatonin-producing function of the epiphysis. J Acad Med Sci Ukr. 2005; 1 (11):136–47.
    12.  
  12. Mukaka MM. Statistics corner: A guide to appropriate use of Correlation coefficient in medical research. Malaw Med J Sept. 2012; 24(3): 69–71.
    13.  
  13. Kochetov AG, Liang OV, Masenko VP, Zhirov IV, Nakonechnikov SV, Tereshchenko SN. Statistical methods of medical data. Moscow, 2012. [Russian]
    14.  
  14. Bondarenko LA. Comparative estimation of season influence on the night melatonin concentration peak formation in young and old rats. Physiol J. 1992; 2(38):111–14. [Russian].
    15.  
  15. Bartsch H, Bartsch C, Mecke D, Lippert TH. Seasonality of pineal melatonin production in the rat: possible synchronization by the geomagnetic field. Chronobiol Int. 1994; 11(1):21–6. CrossRef PubMed
    16.  
  16. Rapoport SI, Malinovskaya NK. Epiphysis – the targetorgan of biotropic action of natural magnetic waves. Bukov Med Herald. 2006; 4(10):13–15. [Russian].
    17.  
  17. Bondarenko LA. The role of interactions between internal and external environmental factors in regulation of pineal gland functional activity. Manuscript. Kyiv, 2003. P.10. [Russian].
    18.  
  18. Belenichev IF, Gubskiy YuI, Llevitsky EL, Kovalenko SI, Marchenko AN. Regulation of antioxidant homeostasis and system detoxication of organizm by hormone melatonin. Role of melatonin dependent receptors in realization of this function. Mod Probl Toxicol. 2003; 2:2–16. [Russian].
    19.  
  19. Johnsson A. Light, circadian and circannual rhythms. Solar Radiat Human Health. Oslo, 2008. P. 57–75.
    20.  
  20. Agadzhanian NA, Radish IV, Khisamutdinov AF. The lipid and hormone metabolism in healthy men in different seasons. Kazan Med J. 2009; 6 (90):776–79. [Russian].
    21.  
  21. Bondarenko LA. Some hormonal mechanisms of accelerated aging at gipopinealizme. Kharkiv, 2015. [Russian].
    22.  
  22. Iarygina VN, Melenteva AS. Manual Gerontology and Geriatrics. Moscow, 2010. [Russian].
    23.  
  23. Belichev IF, Gubskii YI, Levickii EL, Kovalenko SI, Marchenko AN. Regulation of antioxidant homeostasis and detoxification system of the body of the hormone melatonin. The role of melatonin-dependent receptors in this function. Such Probl Toksik. 2003; 2:2–16. [Russian].
    24.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.