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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(6): 60-64


PROGESTERONE RECEPTOR GENE POLYMORPHISMS AS GENETIC RISK FACTOR OF THREATENED ABORTION

O.S. Kryvopustov1, V.E. Dosenko2

  1. O.O. Bogomolets National Medical University, Kyiv, Ukraine;
  2. O.O. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz62.06.060

Abstract

Determination of the progesterone receptor gene polymorphisms rs590688 C/G and rs500760 A/G was provided using PCR method. To investigate the genetical precursors of threatened abortion the next groups were included: 67 patients with threatened abortion and 93 healthy persons. These allelic variants have the significantly different at rs590688 study: C/C - 23,9%, C/G - 44,8%, G/G - 31,3%, and C/C - 27,2%, C/G - 58,7%, G/G - 14,1% in the control group (P<0,05 by x2-test). The allelic variants of the rs500760 polymorphism did not differ statistically in the study group A/A 53,7%, A/G - 40,3%, G/G - 6% in the control group A/A- 52,2%, A/G - 44,6%, G/G - 3,3% (P>0,05 by x2-test). Distribution of minor homozygote G/G polymorphism rs590688 progesterone receptor gene in patients with threatened abortion in our study almost in 10 times higher in comparing with women of Taiwanese Han population, who had idiopathic recurrent pregnancy loss. The obtained data indicate significant ethnic differences in PGR and show polymorphism rs590688 clinical significance.

Keywords: progesterone receptor gene; polymorphism; threatening abortion

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