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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(6): 60-64


O.S. Kryvopustov1, V.E. Dosenko2

  1. O.O. Bogomolets National Medical University, Kyiv, Ukraine;
  2. O.O. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv


Determination of the progesterone receptor gene polymorphisms rs590688 C/G and rs500760 A/G was provided using PCR method. To investigate the genetical precursors of threatened abortion the next groups were included: 67 patients with threatened abortion and 93 healthy persons. These allelic variants have the significantly different at rs590688 study: C/C - 23,9%, C/G - 44,8%, G/G - 31,3%, and C/C - 27,2%, C/G - 58,7%, G/G - 14,1% in the control group (P<0,05 by x2-test). The allelic variants of the rs500760 polymorphism did not differ statistically in the study group A/A 53,7%, A/G - 40,3%, G/G - 6% in the control group A/A- 52,2%, A/G - 44,6%, G/G - 3,3% (P>0,05 by x2-test). Distribution of minor homozygote G/G polymorphism rs590688 progesterone receptor gene in patients with threatened abortion in our study almost in 10 times higher in comparing with women of Taiwanese Han population, who had idiopathic recurrent pregnancy loss. The obtained data indicate significant ethnic differences in PGR and show polymorphism rs590688 clinical significance.

Keywords: progesterone receptor gene; polymorphism; threatening abortion


  1. Farrell T, Owen P. The significance of extrachorionic membrane separation in threatened miscarriage. Br J Obstet Gynaecol 1996;103:926–8. CrossRef PubMed
  3. Saraswat L, Bhattacharya S, Maheshwari A, Bhattacharya. Maternal and perinatal outcome in women with threatened miscarriage in the first trimester: a systematic review. BJOG. 2010;117(3):245-57. CrossRef PubMed
  5. Manukhin I. Gynecological endocrinology. Moscow. GEOTAR Media. 2013. [Russian].
  7. Graham J, Clarke C. Physiological action of progesterone in target tissues. Endocr Rev. 1997;18(4):502-19. CrossRef  
  8. O'Brien J. Progestogen safety: implications for metaanalysis. Ultrasound Obstet Gynecol. 2012;40(4):486-7. CrossRef PubMed
  10. Al-Asmakh M. Reproductive functions of progesterone. Mid East Fertili Soc J. 2007;12(3):197–201.
  12. Barda G, Ben-Haroush A, Barkat J, Malinger G, Luria O, Golan A, Bar J. Effect of vaginal progesterone, administered to prevent preterm birth, on impedance to blood flow in fetal and uterine circulation. Ultrasound Obstet Gynecol. 2010;36(6):743-8. CrossRef PubMed
  14. Romano A, Delvoux B, Fischer DC, Groothuis P. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone. J Mol Endocrinol. 2007;38(1-2):331-50.
  16. Guoyang Luo, Morgan T, Bahtiyar MO, Snegovskikh VV, Schatz F, Kuczynski E, Funai EF, Dulay AT, Huang ST, Buhimschi CS, Buhimschi IA, Fortunato SJ, Menon R, Lockwood CJ, Norwitz ER. Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth. Reprod Sci. 2008;15(2):147-55. CrossRef PubMed
  18. Mills AA, Yonish B, Feng L, Schomberg DW, Heine RP, Murtha AP. Characterization of progesterone receptor isoform expression in fetal membranes. Am J Obstet Gynecol. 2006;195(4):998-1003. CrossRef PubMed
  20. Manuck TA, Lai Y, Meis PJ, Dombrowski MP, Sibai B, Spong CY, Rouse DJ, Durnwald CP, Caritis SN, Wapner RJ, Mercer BM, Ramin SM. Progesterone receptor polymorphisms and clinical response to17-alpha-hydroxyprogesterone caproate. Am J Obstet Gynecol. 2011;205(2):135. CrossRef PubMed PubMedCentral
  22. Kryvopustov O, Dosenko V. Single nucleotide polymorphisms in human progesterone receptor gene and its value in miscarriage or preterm delivery. Fiziol Zh. 2015;61(2):111-19.
  23.   Su MT, Lin SH, Chen YC. Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril. 2011 Dec;96(6):1435-44  
  24. Schweikert A, Rau T, Berkholz A, Allera A, Daufeldt S, Wildt L. Association of progesterone receptor polymorphism with recurrent abortions. Eur J Obstet Gynecol Reprod Biol. 2004;113(1):67-72. CrossRef PubMed
  26. Su MT, Lee IW, Chen YC, Kuo PL. Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population. J Assist Reprod Genet. 2011;28(3):239-43. CrossRef PubMed PubMedCentral
  28. Li Wang, Zeng Chan Wang, Cui Xie, Xiao Feng Liu, Mao Sheng Yang. Genome-wide screening for risk loci of idiopathic recurrent miscarriage in a Han Chinese population: a pilot study. Reprod Sci. 2010;17(6):578-84. CrossRef PubMed

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