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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2004; 50(2): 27-33


VASODILATATORY PROPERTIES OF THE NEW FLUOR-CONTAINING ANALOGUES OF DIAZOXIDE: MECHANISM OF THEIR ACTION

S.N. Pyvovar, R.B. Strutinskii, L.M. Yagupolskii, A.A. Moibenko

  1. A.A. Bogomoletz Institute of Physiology Nationa Academy of Sciences of Ukraine, Kiev


Abstract

On the isolated preparations of rat aorta it was shown that the new fluor-containg analogues of diazoxide (DiazoFp and DiazoFm) elicit asodilatatory effects related to the activation of ATP-sensitive potassium channels. It was established that DiazoFp is a more powerful asodilator than DiazoFm and diazoxide. It was proposed that DiazoFp action consists of two components: direct activation of sarcKATP channels and activation of sarcKATP channels, through activation of mitoKATP channels.

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