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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(3): 64-69


THE EFFECT OF EXOGENOUS MELATONIN ON BONE REMODELING

V.A. Berezovskyі1, I.G. Litovka1, S.P. Veselskyi2, R.V. Janko1, U.A. Zhernoklev1

  1. O.O.Bogomolets Institute of Physiology NAS, Кіеv;
  2. Peter Bohach Institute of Physiology of Kiev National Taras Shevchenko University
DOI: https://doi.org/10.15407/fz61.03.064

Abstract

It was investigated in spring 28-day experiment the administration of pharmacological doses (5 mg/kg) of melatonin to 3-month male rats with high and low levels of energy metabolismat remodeling of bone tissue. It was shown the decrease in activity of osteoblast and increase of osteoclast activity regardless of energy metabolism intensity, increase in concentration of glycosaminoglycans and free amino acids. This indicates the inhibition of physiological bone remodeling and helps to maintain the integrity of the organic matrix and the inorganic component of the fixation of the connective tissue - hydroxyapatite crystals.

Keywords: melatonin; bone tissue.

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