Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(3): 64-69

THE EFFECT OF EXOGENOUS MELATONIN ON BONE REMODELING

V.A. Berezovskyі1, I.G. Litovka1, S.P. Veselskyi2, R.V. Janko1, U.A. Zhernoklev1

  1. O.O.Bogomolets Institute of Physiology NAS, Кіеv;
  2. Peter Bohach Institute of Physiology of Kiev National Taras Shevchenko University
DOI: https://doi.org/10.15407/fz61.03.064


Abstract

It was investigated in spring 28-day experiment the administration of pharmacological doses (5 mg/kg) of melatonin to 3-month male rats with high and low levels of energy metabolismat remodeling of bone tissue. It was shown the decrease in activity of osteoblast and increase of osteoclast activity regardless of energy metabolism intensity, increase in concentration of glycosaminoglycans and free amino acids. This indicates the inhibition of physiological bone remodeling and helps to maintain the integrity of the organic matrix and the inorganic component of the fixation of the connective tissue - hydroxyapatite crystals.

Keywords: melatonin; bone tissue.

Full text: (PDF, in Ukrainian)

References

  1. AnisimovV. Role of melatonin in organism and its practice in. St/ Petersburg: Systema: 2007 [Russian].
    2.  
  2. Nakade O, Koyama H, Ariji H, Yajima A, Kaku T. Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro. J Pineal Res. 1999; 27(2):106-10;
    3.  
  3. Roth JA, Byung-Gook Kim, Fei Song, Wen-Lang Lin, Moon-II Cho. Melatonin promotes osteoblasts differentiation and bone formation. J Biological Chemistry. 1999; 247(45):22041-47. CrossRef  
  4. Ostrowska Z, Wolkowska-Pokrywa K, Kos-Kudla B, Swietochowska E, Marek B, Kajdaniuk D. Melatonin and bone status. Pol. Merkur. Lekarski. 2006; 21(124):389-93.
    5.  
  5. Sanchez-Barcelo EJ, Mediavilla MD, Tan DX, Reiter RJ. Scientific basis for the potential use of melatonin in bone disease: osteoporosis and adolescent idiopathic scoliosis. J Osteoporosis. 2010; 2010(1):1-10. CrossRef PubMed PubMedCentral
    6.  
  6. Suzuki N, Hattori A. Melatonin suppresses osteoclastic and osteoblastic activities in the scales of goldfish. J Pineal Res. 2002; 33(4):253–58. CrossRef PubMed
    7.  
  7. Berezovsky VJ, Lіtovka ІG.,Kostjuchenko OS, Janko RV. Influence of melatonіn on physiological regeneration processes of bone tissueof younf rats. Space Technol. Sci. 2008; 14(3):75-81 [Ukrainian].
    8.  
  8. Berezovsky VJ, Lіtovka ІG, Veselsky SP, Zamorska TM, Janko RV. Influence of exogenous melatonіn on lіpіds and amіno acid warehouse in organіc matrix of bone tissue Space. Technol. Sci. 2012; 18(3):78-82 [Ukrainian].
    9.  
  9. Litovka IG, Berezovsky VA. The organic matrix adaptation and bone remodeling. Donetsk: Publisher Zaslavsky A.:2014[Russian].
    10.  
  10. Klyatskin SA, LifshitzRI. Determination of glycosaminoglycans by ortsinov method in patients blood. Lab Work. 1989; 10:51-53 [Russian].
    11.  
  11. Leontiev VK, PetrovichVK.Biochemical Methods in Clinical and Experimental Dentistry. Omsk: 1976 [Russian].
    12.  
  12. Sharaev PN, Strelkov NS, Guncha VV, Sosulina LL. Determination of hyaluronidase activity in biological fluids. Clin Lab. Diagnostics. 1996; 3:21-22 [Russian].
    13.  
  13. Peter VI, Regerand TI, Lysenko EI. Extraction, separation and quantification of lipid fractions of blood serum. Lab Business.1986; 6:339 [Russian].
    14.  
  14. Way of sample preparation of bіoliquids detecting in lipids determination Nature. Veselskiy SP, Lyaschenko PS, Kostenko S.І., Gorenko ZA, KurovskaLF. Deklaratsіyny patent for vinahіd ;33564A, 15.02.2001. [Ukraine], stated 11.03.1999 -Byul.;1, In Registration 15.02.2001 [Ukrainian].
    15.  
  15. Kaznacheeva AI, Sinister NC. The content of free amino acids in healthy blood plasma, erythrocytes and urine. Lab Work. 1976; 8:479-80 [Russian].
    16.  
  16. Korobeinikova EM, Meshcheriakova GV. Determination of free amino acids in the serum and urine of healthy children. Lab Work. 1981; 4:221-24 [Russian].
    17.  
  17. Satomura K, Tobiume S, Tokuyama R. Melatonin at pharmacological doses enhances human osteoblastic differentiation in vitro and promotes mouse cortical bone formation in vivo. J Pineal Res. 2007; 42(3): 231–39. CrossRef PubMed
    18.  
  18. Schroeder A, Van Der Zypen E, Stich H, Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofacial Surgery.1981; 9(1):15–25. CrossRef  
  19. Penarrocha Diago M, Oltra Moscardo M.J., Sanchis Bielsa J.M. Implantologia Oral. Barcelona, Spain: Ars Medica; 2005. Conceptos generales de implantologia. P.3–17.
    20.  
  20. Greenspan SL. Effect of thyroid hormone on bone / Greenspan SL, Greenspan FS. Mezhd Zh Med Praktiki. 2001; 1:47-55 [Russian].
    21.  
  21. Danilova LI. Thyroid hormones and bone metabolism. Med News. 2001; (9):3-7 [Russian].
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.