THE INFLUENCE OF NANODISPERSE CERIUM DIOXIDE ON ONTOGENETIC CHANGES OF ANTIOXIDANT SYSTEM IN THE MUCOSA OF THE STOMACH AND COLON IN RATS
O.Yu Iefimenko 1, I.O. Savchenko 1, T.M. Falalyeyeva 1, T.V. Beregova1, N.M. Zholobak2, O.B. Shcherbakov 2, Yu.V. Malyukin 3, M. Ya Spivak 2.
- Taras Shevchenko National University of Kyiv;
- Danylo Zaboloty Institute of Microbiology and Virology
National Academy of Science of Ukraine, Kyiv;
- Insitute for Scintillation Materials National Academy of
Science of Ukraine, Kharkiv.
It was established that with age the content of lipid peroxidation
products increased in the mucosa of the stomach: Diene
conjugates by 30%, products which react to thiobarbituric
acid by 285% and Schif bases by 181%. Nanodisperse cerium
dioxide (NCD) reduced the content of lipid peroxidation in the
gastric mucosa in old rats: Diene conjugates by 43 %, products
which react to thiobarbituric acid by 51% and Schif bases by
44% relative to the control group of rats given age. Similarly, it
was established that the content of Diene conjugates increased
by 40%, products which react to thiobarbituric acid by 114%
and Schif bases by 132% in the mucosa of the colon of old
rats. NDC significant reduced the content of products which
react to thiobarbituric acid by 69% and Schyf basics by 132%.
In the stomach superoxide dismutase (by 43%) and catalase
activity (by 24%) decreases with age, while in the colon
superoxide dismutase activity increases (by 43%). In the colon
NCD significant decreased superoxide dismutase (by 34%) and
catalase activity (by 21%) relative to controls. Thus, the NDC
restores lipid peroxidation in the gastric mucosa and colon, in
which develops oxidative stress with age.
nanodisperse cerium dioxid;, lipid peroxidation; mucose of the stomach and colon.
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