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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(2): 94-101


THE EFFECT OF CHRONIC INTOXICATION WITH LOW DOSES OF CHLORPYRIFOS ON THE BEHAVIORAL PARAMETERS OF FEMALE RATS

S.V. Grabovska, Y.T. Salyha

    Instityte of Animal Biology National Academy of Agrarian Scince of Ukraine, Lviv
DOI: https://doi.org/10.15407/fz61.02.094

Abstract

We explored the effect of chronic chlorpyrifos intake on the behavior of female laboratory rats. The animals were exposed to chlorpyrifos in doses 5 and 10 mg/kg daily for a month long and tested with behavioral tests: Morris water maze, Open field test, and Dark/light box. Everyday chlorpyrifos intake in dose 10 mg/kg was revealed to cause long- and short-term spatial memory lesion, decrease in total activity, sharp changes in the level of anxiety (it significantly increased at the start of xenobiotic intake, and then normalized with time). Similar trends, though less intense, were observed in the group exposed to 5 mg/kg chlorpyrifos. From the survey results it can be concluded that long-term (30 days long) intake of even low doses of chlorpyrifos can cause adverse effects on the functional state of nervous system.

Keywords: chlorpyrifos; organophosphates; rats; behavior; memory; Open field; Morris water maze; Light/Dark box.

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