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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(2): 80-86

FULLERENE C[sub]60[/sub] INHIBITED FREE RADICAL AND DESTRUCTIVE PROCESSES IN CONNECTIVE TISSUE DURING ADJUVANT ARTHRITIS IN RATS

T. V. Mamontova, L. E. Vesnina, M. V. Mikityuk, N. A. Bobrova, L. A. Kutsenko, I. L. Gordinskaya, I.P. Kaidashev

    Research Institute for Genetic and Immunological Grounds of Patology and Pharmacogenetic, Ukrainian Medical Stomatological Academy, Poltava
DOI: https://doi.org/10.15407/fz61.02.080


Abstract

The effects of fullerene C60 (FС60) on the level of free radiсal and destruction processes were studied in rats with experimental adjuvant arthritis (AA). It was shown the protective effect of FС60 during AA. The effect was accompanied by an increase of the antioxidant enzymes activity, superoxidedismutase in the liver (15,96±0,38 µmol/kg·s) and in the kidneys (5,36±0,27 µmol/kg·s) and catalase in the kidneys (9,56±0,78 µmol/kg·s) and in the heart (2,26±0,41 µmol/kg·s) in comparison to control group (43,83±5,69 %; 54,55±6,18%; 11,68±0,52 µmol/kg·s; 3,43±0,47 µmol/kg·s; 4,77±0,5 µmol/kg·s; 0,98±0,12 µmol/kg·s accordingly). It was shown a protective effect of FС60 during AA directed on the depression of the destructive processes in connective tissue that was expressed through the reduction of the total collagenolitic activity level in cartilage (10,05 ± 0,06 µmol/g/min) and bone (11,21±0,04 µmol/g/min) tissues, free hydroxyproline contents (1,54±0,04 µg/ml) and alkaline phasphatase activity (1,24±0,14 µmol/l·sec) in comparison to control group (11,91 ± 0,49 µmol/g/min; 13,19±0,15 µmol/g/min; 2,25±0,07 µg/ ml; 2,19±0,24 µmol/l·sec accordingly). Taken together, these results accentuate the perspective of future investigations of action FС60 during rheumatoid arthritis as a feasible therapeutic agent.

Keywords: experimental adjuvant arthritis; fullerene C60; antioxidant enzymes activity; total collagenolitic activity.

Full text: (PDF, in Ukrainian)

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