Impact of C[sub]60[/sub] fullerene on the dynamics of force-speed changes in soleus muscle of rat at ischemia-reperfusion injury
D.M. Nozdrenko1, K.I. Bogutska1, Yu.I. Prylutskyy1, V.F. Korolovych1,2, M.P. Evstigneev3, U. Ritter4, P. Scharff4
- Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
- Saratov State University, Saratov, Russia;
- Department of Biology and Chemistry, Belgorod State University, Belgorod, Russia;
- Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, Germany
DOI: https://doi.org/10.15407/fz61.02.048
Abstract
The effect of C 60 fullerene nanoparticles (30-90 nm) on dynamics of force response development to stimulated
soleus muscle of rat with ischemic pathology, existing in muscle during the first 5 hours and first 5 days
after 2 hours of ischemia and further reperfusion, was investigated using the tensometric method. It was
found that intravenous and intramuscular administration of С 60 fullerene with a single dose of 1 mg/kg
exert different therapeutic effects dependent on the investigated macroparameters of muscle contraction.
The intravenous drug administration was shown to be the most optimal for correction of the velocity
macroparameters of contraction due to muscle tissue ischemic damage. In contrast, the intramuscular
administration displays protective action with respect to motions associated with generation of maximal
force response or continuous contractions elevating the level of muscle fatigue. Hence, С 60 fullerene, being
a strong antioxidant, may be considered as a promising agent for effective therapy of pathological states
of the muscle system caused by pathological action of free radical processes
Keywords:
C[sub]60[/sub] fullerene, soleus muscle of rat, ischemia-reperfusion injury, dynamics of muscle contraction, dynamic light scattering.
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