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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(2): 48-59


Impact of C[sub]60[/sub] fullerene on the dynamics of force-speed changes in soleus muscle of rat at ischemia-reperfusion injury

D.M. Nozdrenko1, K.I. Bogutska1, Yu.I. Prylutskyy1, V.F. Korolovych1,2, M.P. Evstigneev3, U. Ritter4, P. Scharff4

  1. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
  2. Saratov State University, Saratov, Russia;
  3. Department of Biology and Chemistry, Belgorod State University, Belgorod, Russia;
  4. Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, Germany
DOI: https://doi.org/10.15407/fz61.02.048

Abstract

The effect of C60 fullerene nanoparticles (30-90 nm) on dynamics of force response development to stimulated soleus muscle of rat with ischemic pathology, existing in muscle during the first 5 hours and first 5 days after 2 hours of ischemia and further reperfusion, was investigated using the tensometric method. It was found that intravenous and intramuscular administration of С 60 fullerene with a single dose of 1 mg/kg exert different therapeutic effects dependent on the investigated macroparameters of muscle contraction. The intravenous drug administration was shown to be the most optimal for correction of the velocity macroparameters of contraction due to muscle tissue ischemic damage. In contrast, the intramuscular administration displays protective action with respect to motions associated with generation of maximal force response or continuous contractions elevating the level of muscle fatigue. Hence, С 60 fullerene, being a strong antioxidant, may be considered as a promising agent for effective therapy of pathological states of the muscle system caused by pathological action of free radical processes

Keywords: C[sub]60[/sub] fullerene, soleus muscle of rat, ischemia-reperfusion injury, dynamics of muscle contraction, dynamic light scattering.

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