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SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN PROGESTERONE RECEPTOR GENE AND ITS VALUE IN MISCARRIAGE OR PRETERM DELIVERY
O.S. Kryvopustov1 , V.E. Dosenko2
- O.O.Bogomoletz National Medical University;
- O.O.Bogomoletz Institute of Physiology of National
Academy of Sciences of Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz61.02.111
Abstract
This article presents the current understanding of progesterone
and its role in female reproductive function, described the
structure and functionality of the progesterone receptor. The
attention is focused on the meaning of the terms miscarriage
and preterm delivery. Was described the today known causes
of the miscarriage and preterm delivery, shown the value
of single nucleotide polymorphisms of the progesterone
receptor in miscarriage and preterm delivery by the analysis
of publications in recent years in order to find connections
between different polymorphisms of the progesterone receptor
gene and a spontaneous abortion, premature labor, recurrent
miscarriage and its impact on progesterone therapy.
Keywords:
progesteron; progesteron receptor polimorphism; miscarrige; spontaneous abortion; premature birth.
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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
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