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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(2): 102-110


ROLE OF SEROTONIN IN THE REGULATION OF RESPIRATION AND BILE SECRETORY FUNCTION OF THE LIVER

P.I. Yanchuk, S.M. Athamnah, E.M. Reshetnik, J.A. Levadyanska, N.O. Nikitina, S.P. Veselsky

    Taras Shevchenko National University of Kyiv
DOI: https://doi.org/10.15407/fz61.02.102

Abstract

In acute experiments on laboratory male rats we have shown that serotonin (10 mkg / kg, intraportal) increased the oxygen consumption of by liver on 28.8% (Р <0.001) and reduced oxygen tension levels on 19.3% (Р <0.001). The action of serotonin on tissue respiration in liver realized through 5-HT2 receptors because previous blockade by ketanserin (3 mg / kg) led to remove the effects of exogenous serotonin and inhibition of the action of endogenous autacoid. Serotonin reduced the amount of secreted bile on 13.5% (Р <0.05), and increases the concentration of conjugated bile acids and decreases the content of free cholate, indicating enhanced conjugation with taurine and glycine in the liver cells. However, serotonin didn’t stimulate synthesis of primary bile acids. Introduction of serotonin in the conditions of 5-HT2 receptors blockade by ketanserin also led to speed decrease of bile secretion, but in this case stimulating effect of autacoid on bile acid conjugation with taurine and glycine wasn’t manifested and content of free cholate wasn’t reduced

Keywords: serotonin; 5-HT[sub]2[/sub] receptors; liver; oxygen tension and oxygen consumption; bile, bile acids.

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