ROLE OF SEROTONIN IN THE REGULATION OF RESPIRATION AND BILE SECRETORY FUNCTION OF THE LIVER
P.I. Yanchuk, S.M. Athamnah, E.M. Reshetnik, J.A. Levadyanska, N.O. Nikitina, S.P. Veselsky
Taras Shevchenko National University of Kyiv
DOI: https://doi.org/10.15407/fz61.02.102
Abstract
In acute experiments on laboratory male rats we have shown
that serotonin (10 mkg / kg, intraportal) increased the oxygen
consumption of by liver on 28.8% (Р <0.001) and reduced
oxygen tension levels on 19.3% (Р <0.001). The action of
serotonin on tissue respiration in liver realized through 5-HT 2
receptors because previous blockade by ketanserin (3 mg / kg)
led to remove the effects of exogenous serotonin and inhibition
of the action of endogenous autacoid. Serotonin reduced the
amount of secreted bile on 13.5% (Р <0.05), and increases
the concentration of conjugated bile acids and decreases the
content of free cholate, indicating enhanced conjugation with
taurine and glycine in the liver cells. However, serotonin
didn’t stimulate synthesis of primary bile acids. Introduction
of serotonin in the conditions of 5-HT 2 receptors blockade by
ketanserin also led to speed decrease of bile secretion, but in
this case stimulating effect of autacoid on bile acid conjugation
with taurine and glycine wasn’t manifested and content
of free cholate wasn’t reduced
Keywords:
serotonin; 5-HT[sub]2[/sub] receptors; liver; oxygen tension and oxygen consumption; bile, bile acids.
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