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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2016; 62(5): 3-11

Experimental therapy of graft-versus-host disease by mesenchymal stromal cells grown on oxide nanocoatings

A.N. Goltsev1, I.V. Rassokha1, T.G. Dubrava1, L.V. Ostankova1, M.V. Ostankov1, V.I. Safonov2, A.V. Zykova2

  1. Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences, Kharkiv
  2. National Science Center ‘Kharkov Institute of Physics and Technology’ of the National Academy of Sciences, Kharkiv


Immune aggression to transplanted allogeneic bone marrow, i.e. the graft-versus-host disease (GVHD), could be decreased by the suppression of effector and/or activation of T- regulatory cells (Тreg). This task could be solved by co-transplantaiton of allogeneic bone marrow and mesenchymal stromal cells (MSCs). This study demonstrated the elevated immune modulating activity of MSCs by their culturing in vitro on Al2O3 oxide nanocoatings. Introduction of the cells to the animals with GVHD resulted in an increased content of Treg in the spleen of bone marrow recipients, reduced severity of the pathology, and higher survival of animals. The findings could be the basis for developing the new approaches to optimize the GVHD treatment methods involving the oxide nanocoating cultured MSCs

Keywords: nanocoatings; mesenchymal stromal cells; graft-versus-host disease


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