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Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=17">Fiziol. Zh. 2015;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=91">61(6):</a> 3-10
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(6): 3-10


HYDROGEN SULFIDE DONOR, NAHS, RECOVERS CONSTITUTIVE NO SYNTHESIS AND ENDOTHELIUM-DEPENDENT RELAXATION OF ISOLATED AORTA IN OLD RATS

K.O. Drachuk, A.V. Kotsjuruba, V.F. Sagach

    Bogomoletz Institute of Physiology, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz61.06.003

Abstract

The objective of this study was to show the effect of H2S donor, NaHS on the endothelium-dependent vasorelaxation, free radical state and cNOS uncoupling in old rats. In the aorta of old rats a combined oxidative and nitrosative stress develops that leads to сNOS uncoupling and decreased constitutive synthesis of the NO. That biochemical changes correlate with lowering of the endothelium-dependent relaxation of aortic smooth muscles (7,5 ± 1,4,%, compared with 64,9 ± 3,5,% in adults) . It was found that, due to the combined inhibition of oxidative and nitrosative stress, NaHS restores constitutive de novo synthesis of NO by restoring сNOS coupling. Additionally, NaHS improves endothelium-dependent vasorelaxation by increasing (by 6,5 times) Ach-induced relaxation of aortic smooth muscles

Keywords: aging; endothelial dysfunction; oxidative stress; nitrosative stress; cNOS uncoupling; hydrogen sulfide; nitric oxide

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