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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(1): 3-9


NANOCERIUM RESTORES THE ERYTHROCYTES STABILITY TO ACID HEMOLYSIS BY INHIBІTION OF OXYGEN AND NITROGEN REACTIVE SPECIES IN OLD RATS

A.V. Kotsuruba1, B.S. Kopjak1, V.F. Sagach1, N.Ja.Spivak2

  1. O.O. Bogomoletz Institute of physiology NAS of Ukraine, Kyiv
  2. Institute of microbiology and virusology NAS of Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz61.01.003

Abstract

In experiments in vivo the effect of nanocerium (cerium oxide nanoparticles) on the stability of red blood cells to acid hemolysis, levels of both ROS and RNS generation and H2S pools in plasma and erythrocytes of old rats were investigated. In red blood cells of old rats the proton penetration into the matrix of erythrocytes showed a significant raising and the fate of labile «aging» erythrocytes in old animals compared with adult were upregulated. These phenomena paralleled with significant up-regulation of ROS and RNS generation. Introduction for 14 days per os to old rats 0.1 mg / kg of nanocerium fully restored resistance of erythrocytes to acid hemolysis by ROS and RNS in both plasma and erythrocytes reduction. Nanocerium decreased the erythrocytes and, conversely, significantly increased the plasma’s pools of H2S. Key words: erythrocytes, acid hemolysis, old rats, proton penetration, cerium oxide nanoparticles, reactive oxygen and nitrogen metabolites, H2S.

Keywords: erythrocytes, acid hemolysis, old rats, proton penetration, cerium oxide nanoparticles, reactive oxygen and nitrogen metabolites, H2S.

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