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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2015; 61(1): 19-27


Association of allelic polymorphisms of genes matrix Gla-protein system with ischemic atherothrombotic stroke

V.Yu. Garbuzova1, D.A. Stroy2, V.E. Dosenko2, Ye.I. Dubovyk1, A.O. Borodenko1, K.A. Shimko1, O.A. Obukhova1, O.V. Ataman1

  1. Sumy State University
  2. O.O.Bogomoletz Institute of Physiology of NAS Ukraine, Kyiv
DOI: https://doi.org/10.15407/fz61.01.019

Abstract

There are results of the determination of 10 polymorphisms of matrix Gla-protein system (gene MGP – T-138→С (rs1800802), G-7→A (rs1800801), Thr83→Ala (rs4236), gene VDR – FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232 ), TaqI (rs731236), gene GGCX – Arg325→Gln (rs699664), gene VKORS1 – T2255→C (rs2359612), gene BMP-2 – Ser37→Ala (rs2273073)) into 170 patients with ischemic atherothrombotic stroke (IATS) and 124 healthy individual is (control group). It is established that there is a connection between the IATS and polymorphic variants of genes MGP (G-7→A) and VKORC1 (T2255→C). The risk of IATS in carriers of minor allele A/A (G-7→A polymorphism) in 2.6 times higher than in carriers of the major allele (G/A + G/G), and C/C genotype (T2255→C polymorphism) in 2.2 times higher than the homozygotes of major allele. The coincidence of patients T/C and G/G, C/C and G/A genotypes, and A/A genotype (G-7→A polymorphism) with any genotype T2255→C polymorphism are increases the risk of IATS.

Keywords: matrix Gla-protein; gene polymorphism; ischemic atherothrombotic stroke

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