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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 69-74



    Kharkiv National pharmaceutical University, Kharkiv, Ukraine


The paper represents the study results of hemostasis in pregnant SHR rats. It is found that in the group of pregnant SHR rats the coagulation shifts are frequently observed, accompanied by fibrinolysis delay, hyperfibrynohenemia and changes in 2- and more hemostasis chains, indicating the higher thrombogenic potential in SHR group. The hemostasis quantitative performance at 19-20 days of gestation in a group of pregnant rats shows higher rates reliability of platelet aggregation with adenosine diphosphate and epinephrine in comparison with animals having physiological pregnancy. Platelet aggregation with collagen is increased in SHR- rats than in pregnant rats with hypertension. In the same period of gestation (19-20 days ), higher levels of fibrinogen and soluble fibrin monomer complexes , and the frequency of positive ethanol test were fixed in pregnant SHR rats compared with the group without hypertension. This confirms the growing thrombogenic potential of blood coagulation in SHR rats. The euhlobulin lysis performance was significantly higher in pregnant rats with hypertension than in the group without hypertension and control. Correlative analysis between fibrinogen levels and indicators was conducted. It reflected the fibrinolytic system state at 19-20 days of gestation and revealed a weak relationship between them independently of fibrinolysis slowing hyperfibrynohenemia in pregnant group.

Keywords: SHR-rats, gestation, vascular-platelet hemostasis,coagulation hemostasis, anticoagulant system, arterialhypertension.


  1. Dobrokhotova JE, Dzhalbava EM, Stepanyan AV. Actual issues of miscarriage: a collection of clinical lectures. Moscow: Medicina; 2007 [Russian].
  3. Alyautdinov OS. Importance of the hemostatic system research in patients with uncomplicated pregnancy and predicting thrombohemorrhagic complications. Obstetrics and Gynecology. 1999; (2):18-23 [Russian].
  5. Barkagan ZS, Momot AP. Diagnosis and treatment of hemostatic disorders controlled. Moscow: Nyudiamed; 2008 [Russian]. PubMed
  7. Belugina OS. Diagnosis of hemostatic disorders in pregnant women with placental insufficiency and neonatal. Siberian Medical Journal. 2010; 25(4):57-59[Russian].
  9. Vartapetova IV. Hypertension during pregnancy. Preeclampsia. Eclampsia. Moscow: FGBI «Scientific Center for Obstetrics, Gynecology and Perinatology;2012 [Russian].
  11. Krivtsova EV, Vertkin AL. Issues of planned and emergency treatment of extragenital diseases in pregnant women. Moscow: Obstetrics and gynecology.2010;(4):37-40 [Russian].
  13. Repina MA. Preeclampsia as a cause of maternal mortality. Obstetrics and women diseases. 2000; (3):11-18 [Russian].
  15. Sernov LN. Statistical methods for assessing the reliability of the results of pharmacological studies. Moscow: Elements of Experimental Pharmacology. 2000;308-15[Russian].
  17. Sidelnikova VM. Haemostasis and pregnancy. Moscow: Triad. 2004 [Russian].
  19. Stryuk RI. Pharmacotherapy and analysis of pregnancy and perinatal outcomes in women with hypertension. Cardiology. 2009;12:29-32.
  21. Schiffman EM. Pre-eclampsia, eclampsia, HELLP - syndrome. Petrozavodsk. 2002;353-75.
  23. Agnieszka, SM. Inherited thrombophilia in women with recurrent miscarriages and pregnancy loss in anamnesis - own experience text. Ginekol Pol. 2008;79(9): 630-34.
  25. Bates SM. Venous thromboembolism, thrombophilia, antithrombotic therapy and pregnancy: American College of Chest Physicians Evidence. Based Clinical Practice Guidelines (8th Edition). 2008; 133:844-60. CrossRef  
  26. Bellamy L, Casas JP, Hingoroni AD, Williams DJ. Preeclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 2007; 974-82. CrossRef PubMed PubMedCentral
  28. Hawkins TL, Roberts JM. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. BJOG 2012; 119:484-92. CrossRef PubMed

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