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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 69-74


HEMOSTATIC FEATURES IN HYPERTENSIVE PREGNANT RATS

E.L.Toryanik

    Kharkiv National pharmaceutical University, Kharkiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.069

Abstract

The paper represents the study results of hemostasis in pregnant SHR rats. It is found that in the group of pregnant SHR rats the coagulation shifts are frequently observed, accompanied by fibrinolysis delay, hyperfibrynohenemia and changes in 2- and more hemostasis chains, indicating the higher thrombogenic potential in SHR group. The hemostasis quantitative performance at 19-20 days of gestation in a group of pregnant rats shows higher rates reliability of platelet aggregation with adenosine diphosphate and epinephrine in comparison with animals having physiological pregnancy. Platelet aggregation with collagen is increased in SHR- rats than in pregnant rats with hypertension. In the same period of gestation (19-20 days ), higher levels of fibrinogen and soluble fibrin monomer complexes , and the frequency of positive ethanol test were fixed in pregnant SHR rats compared with the group without hypertension. This confirms the growing thrombogenic potential of blood coagulation in SHR rats. The euhlobulin lysis performance was significantly higher in pregnant rats with hypertension than in the group without hypertension and control. Correlative analysis between fibrinogen levels and indicators was conducted. It reflected the fibrinolytic system state at 19-20 days of gestation and revealed a weak relationship between them independently of fibrinolysis slowing hyperfibrynohenemia in pregnant group.

Keywords: SHR-rats, gestation, vascular-platelet hemostasis,coagulation hemostasis, anticoagulant system, arterialhypertension.

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