EFFECTS AND QUINPEROLE AND SULPIRIDE ON EMOTIONAL BEHAVIORS IN FEMALE RATS
Yu.O. Fedotova1, G.O. Frolova2
- I.P. Pavlov Institute of Physiology, RAS, St. Petersburg, Russia
- Donetsk National University, Donetsk, Ukraine
DOI: https://doi.org/10.15407/fz60.06.041
Abstract
The present work was devoted to the comparative analysis of
influence of chronic administration of D2-receptors agonist
– quinperole (0,1 mg/kg, i.p.) and D2-receptors antagonist
– sulpiride (10,0 mg/kg, i.p.) for 14 days on anxiety and
depressive-like behavior in the adult female rats. Model of
depression in rats was carried out in Porsolt test. Anxiety level
was assessed in the elevated plus maze. It was established that
chronic quinperoe administration rendered an anxiolytic action
in females during diesrous, estrous and proestrous phases, but
failed to modify depression-like behavior during ovary cycle.
Sulpiride administration resulted in anxiogenic effect in all
phases of ovary cycle in females. Also, it was noted definite
modulation of depression-like behavior in connection of ovary
cycle phases in rats treated with sulpiride: at moderate level of
estrogens was prodepressive action while at reduced/enhanced
levels of estrogen – antidepressant effect. It is suggested different
extent of D2-receptors receptors involvement in the mechanisms
of anxiety-depressive-like behavior at alterations of hormonal
balance during ovary cycle. The data obtained indicate in a
close interaction between ovary hormonal and dopaminergic
systems of the brain in mechanisms of anxiety and depression.
Keywords:
квинпирол, сульпирид, депрессия, тре-вожность, половой цикл, эстрогены, самки.
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