The present work was devoted to the comparative analysis of influence of chronic administration of D2-receptors agonist – quinperole (0,1 mg/kg, i.p.) and D2-receptors antagonist – sulpiride (10,0 mg/kg, i.p.) for 14 days on anxiety and depressive-like behavior in the adult female rats. Model of depression in rats was carried out in Porsolt test. Anxiety level was assessed in the elevated plus maze. It was established that chronic quinperoe administration rendered an anxiolytic action in females during diesrous, estrous and proestrous phases, but failed to modify depression-like behavior during ovary cycle. Sulpiride administration resulted in anxiogenic effect in all phases of ovary cycle in females. Also, it was noted definite modulation of depression-like behavior in connection of ovary cycle phases in rats treated with sulpiride: at moderate level of estrogens was prodepressive action while at reduced/enhanced levels of estrogen – antidepressant effect. It is suggested different extent of D2-receptors receptors involvement in the mechanisms of anxiety-depressive-like behavior at alterations of hormonal balance during ovary cycle. The data obtained indicate in a close interaction between ovary hormonal and dopaminergic systems of the brain in mechanisms of anxiety and depression.