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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 36-40


L.N. Plotnikova, V.A. Berezovskiі

    O.O.Bogomoletz Institute of Physiology NAS of Ukraine, Kyiv, Ukraine


We investigated the effect of a low partial oxygen pressure (Pо2) on the proliferation and alkaline phosphatase activity of human fibroblast-like cells line 4BL, isolated from blood. The cells incubation for 3 days (8 hours daily) at the level of Pо2 38 and 76 mm Hg stimulates the proliferative potential of their by 27 and 45% respectively, compared to the control. It was shown a reduction in the activity of alkaline phosphatase (a marker of bone formation) by 25% while reducing Pо2. Our data suggest inhibition of osteogenic differentiation of cells line 4BL when the oxygen concentration in the gas atmosphere of 5 and 10% O2 compared with control (21% O2).

Keywords: fibroblast-like cells, oxygen partial pressure,proliferation, differentiation.


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