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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 22-26


N.A. Dorofeyeva, K.O. Drachuk, V.F.Sagach

    O.O.Bogomoletz Institute of Physiology NAS of Ukraine, Kyiv, Ukraine


We studied cardiohemodynamics and the efficiency of Frank–Starling mechanism in aged and adult Wistar rats, using pressure-volume (PV) conductance catheter system (Millar Instruments, USA) in order to evaluate systolic and diastolic function in vivo. We found left ventricular diastolic dysfunction and impaired relaxation of the heart in aged rats, which is indicated by the reduction in the maximum rate of pressure drop with an increase in end-diastolic stiffness and active relaxation constant. Our results showed a decreased efficiency of Frank-Starling mechanism (ДSV/ДEDV) in aged rats. However, we have shown a 70 % increases in oxygen consumption and 1.7 times increased stroke work of the hearts of old rats. Our results suggest that heart of old rats with the same stroke volume perform most stroke work, with greater oxygen consumption. This indicates that the heart of old rats worked less effectively, with greater oxygen consumption. Key words: aging, heart, cardiohemodynamics, Frank-Starling mechanism.

Keywords: aging, heart, cardiohemodynamics, Frank-Starlingmechanism.


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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.