Українська English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(6): 22-26

CARDIOHEMODYNAMICS AND EFFICIENCY OF FRANK–STARLING MECHANISM DURING AGING

N.A. Dorofeyeva, K.O. Drachuk, V.F.Sagach

    O.O.Bogomoletz Institute of Physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.022


Abstract

We studied cardiohemodynamics and the efficiency of Frank–Starling mechanism in aged and adult Wistar rats, using pressure-volume (PV) conductance catheter system (Millar Instruments, USA) in order to evaluate systolic and diastolic function in vivo. We found left ventricular diastolic dysfunction and impaired relaxation of the heart in aged rats, which is indicated by the reduction in the maximum rate of pressure drop with an increase in end-diastolic stiffness and active relaxation constant. Our results showed a decreased efficiency of Frank-Starling mechanism (ДSV/ДEDV) in aged rats. However, we have shown a 70 % increases in oxygen consumption and 1.7 times increased stroke work of the hearts of old rats. Our results suggest that heart of old rats with the same stroke volume perform most stroke work, with greater oxygen consumption. This indicates that the heart of old rats worked less effectively, with greater oxygen consumption. Key words: aging, heart, cardiohemodynamics, Frank-Starling mechanism.

Keywords: aging, heart, cardiohemodynamics, Frank-Starlingmechanism.

Full text: (PDF, in Ukrainian)

References

  1. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schulman SP, et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol. 1995;78(3):890-900. CrossRef PubMed
    2.  
  2. Lakatta EG, Levy D. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises. Part II: The Aging Heart in Health: Links to Heart Disease. Circ. 2003;107(2):346-54. CrossRef  
  3. Schmidt U, Zhu X, Lebeche D, Huq F, Guerrero JL, Hajjar RJ. In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts. Cardiovasc Res. 2004;66(2):318-23. CrossRef PubMed
    4.  
  4. Goshovska YV, Lisovyi II, Shimanskaya TV, Sagach VF. UCP2 and UCP3 genes expression, heart function and oxygen cost of myocardial work changes during aging and ischemia-reperfusion. Fiziol Zh. 2009;55(3):26-36.
    5.  
  5. Frolkis VV, Bezrukov VV, Shevchuk VG. Circulation and aging. Leningrad: Nauka; 1984.
    6.  
  6. Korkushko OV, Dolot IV. Age-related changes in morphofunctional state of the heart. Fiziol Zh. 2001;47(1):26-33. PubMed
    7.  
  7. Moslehi J, DePinho RA, Sahin E. Telomeres and Mitochondria in the Aging Heart. Circ Res. 2012;110(9):1226-37. CrossRef PubMed PubMedCentral
    8.  
  8. Shumakov VI, Tolpekin VE. Assisted circulation. Moskow; 1980.
    9.  
  9. Cingolani HE, Perez NG, Cingolani OH, Ennis IL. The Anrep effect: 100 years later. Am J Physiol Heart Circ Physiol. 2013;304(2):175-82. CrossRef PubMed
    10.  
  10. Burkhoff D, Mirsky I, Suga H. Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol.2005;289(2):501-12. CrossRef PubMed
    11.  
  11. Pacher P, Nagayama T, Mukhopadhyay P, Batkai S, Kass DA. Measurement of cardiac function using pressurevolume conductance catheter technique in mice and rats. Nat Protoc. 2008;9:1422-34. CrossRef PubMed PubMedCentral
    12.  
  12. Suga H. Ventricular energetics. Physiol Rev. 1990; 70(2):247-77. CrossRef PubMed
    13.  
  13. Sagach VF, Vavilova GL, Strutynska NA, Rudyk OV. The aging increase in the sensitivity of the mitochondrial permeability transition pore opening to inductors in rat heart. Fiziol Zh. 2004;50(2):49-63.
    14.  
  14. Tkachenko MN, Sagach VF, Kotsjuruba AV, Baziljuk OV, Buchanevich AM, Meged EF, et al. Endotheliumdependent contractile reactions of vascular smooth muscles and content of free radicals of oxygen of rats in aging. Fiziol Zh. 2002;48(4):3-13.
    15.  
  15. Kuka S, Tatarkova Z, Racay P, Lehotsky J, Dobrota D, Kaplan P. Effect of aging on formation of reactive oxygen species by mitochondria of rat heart. Gen Physiol Biophys. 2013;32(3):415-20. CrossRef PubMed
    16.  
  16. Stojkovski V, Hadzi-Petrushev N, Ilieski V, Sopi R, Gjorgoski I, Mitrov D et al. Age and heat exposure-dependent changes in antioxidant enzymes activities in rat's liver and brain mitochondria: role of alpha-tocopherol. PhysiolRes.2013;65(2):503-10.
    17.  
  17. Preston CC, Oberlin AS, Holmuhamedov EL, Gupta A, Sagar S, Syed RH, et al. Aging-induced alterations in gene transcripts and functional activity of mitochondrial oxidative phosphorylation complexes in the heart. Mech Ageing Dev. 2008;129(6):304-12. CrossRef PubMed PubMedCentral
    18.  
  18. Desler C, Hansen TL, Frederiksen JB, Marcker ML, Singh KK, Juel Rasmussen L. Is there a link between mitochondrial reserve respiratory capacity and aging? J Aging Res. 2012. CrossRef PubMed PubMedCentral
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2025.