CARDIOHEMODYNAMICS AND EFFICIENCY OF FRANK–STARLING MECHANISM DURING AGING
N.A. Dorofeyeva, K.O. Drachuk, V.F.Sagach
O.O.Bogomoletz Institute of Physiology NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.06.022
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Abstract
We studied cardiohemodynamics and the efficiency of
Frank–Starling mechanism in aged and adult Wistar rats,
using pressure-volume (PV) conductance catheter system
(Millar Instruments, USA) in order to evaluate systolic and
diastolic function in vivo. We found left ventricular diastolic
dysfunction and impaired relaxation of the heart in aged rats,
which is indicated by the reduction in the maximum rate of
pressure drop with an increase in end-diastolic stiffness and
active relaxation constant. Our results showed a decreased
efficiency of Frank-Starling mechanism (ДSV/ДEDV) in aged
rats. However, we have shown a 70 % increases in oxygen
consumption and 1.7 times increased stroke work of the hearts
of old rats. Our results suggest that heart of old rats with the
same stroke volume perform most stroke work, with greater
oxygen consumption. This indicates that the heart of old rats
worked less effectively, with greater oxygen consumption.
Key words: aging, heart, cardiohemodynamics, Frank-Starling
mechanism.
Keywords:
aging, heart, cardiohemodynamics, Frank-Starlingmechanism.
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