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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(5): 99-104

Experimental correction of metabolic changes in mouth at long-term hypoacidity by multiprobiotic "Symbiter acidophilic"

Manko AM1, Neporada KS1, Sukhomlyn AA1, Ghasemzadeh J1, Beregova TV2, Yankovskiy DS3

  1. Ukrainian Medical Stomatological Academy, Poltava, Ukraine
  2. Taras Shevchenko National Universityof Kyiv, Ukraine
  3. Scientific Production Company «O.D. Prolisok», Kyiv, Ukraine


It is known, that long decrease in gastric secretion leads to the development of hypergastrinemia, dysbiosis and to pathological changes in digestive organs. Very important there is a search of ways to correction of these undesirable consequences. Long-term usage of omeprazole leads to metabolic disorders in periodontium tissues and salivary glands, such as development of NO-ergic system disbalance and activation of freeradical oxidation, that are positively corrected by multiprobiotic of new generation “Symbiter acidophilic”.

Keywords: periodontium, salivary glands, omeprazole, hypoacidity, hypergastrinemia, dysbiosis, “Symbiter acidophilic ”


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