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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(5): 82-88


Effect of C60 fullerene on viscoelastic properties of human erythrocytes membrane

Shpakova NM1, Nipot OS1, Ishchenko IO1, Pryluts'ka SV2, Bohuts'ka KI2, Cherepanov VV3, Sandomyrs'kyĭ BP1, Pryluts'kyĭ IuI2

  1. Institute for Problems of Cryobiology and Cryomedicine ofNAS of Ukraine, Kharkiv, Ukraine
  2. Taras Shevchenko National University of Kyiv, Ukraine
  3. Institute of Physics of NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.05.082

Abstract

The effect of С60 fullerene aqueous colloid solution (C60FAS) on viscoelastic properties of human erythrocytes membrane has been studied. It was established that the effect of C60FAS on erythrocytes depends on the medium osmolality and concentration of С60 fullerene in it. In particular, in isotonic solution (0,15 mole/L NaCl) adding С60 fullerene in concentrations from 0,7 до 28 mmole/L did not cause the hemolytic damage of cells. In hypotonic medium when introducing С60 fullerene (7 mmole/L concentration) at the beginning of erythrocyte hemolysis its stimulating effect was maximal and when adding C60FAS in 20 s after hemolysis start no this process stimulation is observed. This points to the changes in viscoelastic properties of erythrocyte membranes even during the first seconds of its interaction with C60 fullerene.

Keywords: С60 fullerene aqueous colloid solution, humanerythrocytes, viscoelastic properties of membrane, atomicforcemicroscopy.

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