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Modulation of rat myometrium contractile activity by peptidoglycan of Staphylococcus aureus cell wall
Nasibian LS, Filippov IB
O.O.Bogomoletz Institute of Physiology of the NationalAcademy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.05.062
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Abstract
Peptidoglycan of Staphylococcus aureus cell wall impact on
the both estrogen- treated and pseudopragnant rat myometrium
contractile activity dynamics was studied. The results of experiments
shown that rat myomatrium sensitivity to peptidoglican
depends on the hormonal background. Peptidoglycan modified
the myometrium contractile activity of both estrogen-treated
and pseudopragnant rats. In estrogen-treated rat myometrium
peptidoglycan reduces frequency and duration of contractions
(elongated the uterine cycle) while in the pseudopregnant rat
myometrium it increased the amplitude as well as the duration
and the freqwency (deshortened the uterine cycle). During
the experiments we found that peptidoglycan has stronger
uterotonic effect than prostaglandin F2?. In this connection
we conclude that the changes of myometral contractile activity
after peptidoglycan action may have negative effects for
fertility and course of pregnancy.
Keywords:
Myometrium, contractile activity, Staphylococcusaureus, peptidoglycan, pseudopregnancy.
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