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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 105-107


Oxidative stress development in the tissues of salivary glands of rats in conditions of monosodium glutamate-induced obesity

Hordiienko LP1, Berehova TV2, Neporada KS1, Falalieieva TM1

  1. Ukrainian Medical Dental Academy, Poltava, Ukraine
  2. The Institute of Biology, Taras Shevchenko NationalUniversity, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.04.105

Abstract

Pathogenic mechanisms of damage of salivary glands under obesity are an insufficiently studied problem of modern medicine. On experimental model of obesity induced by monosodium glutamate, free-radical processes and antioxidant defense system were studied in the tissues of salivary glands of rats. Under experimental obesity induced by monosodium glutamate there is a significant increase of the content of thiobarbituric acid reactive substances and a significant decreasе in the activity of superoxide dismutase and catalase. Thus, it indicates to the misbalance of prooxidant and antioxidant systems and the development of oxidative stress. Key words: salivary glands, obesity, monosodium glutamate, oxidative stress.

Keywords: salivary glands, obesity, monosodium glutamate,oxidative stress.

References

  1. Benza TM. Dietary therapy of obesity. Endokrynologia. 2012;17(1):102-5. [Russian]. Afanas'ev VV, Striuk RI, Arutiunian SE, Eliseeva LV, Bychkov RA. Reactive-dystrophic processes in salivary glands (sialoadenoses) running on the background of metabolic syndrome. Stomatologiia. 2011;90(4):49-53. [Russian].
  2.  
  3. He K, Zhao L, Daviglus ML, Dyer AR, Horn LV, Garside D, et al. Association of monosodium glutamate intake with overweight in Chinese adults: the INTERMAP Study. Obesity. 2008;16(8):1875-80. CrossRef PubMed PubMedCentral
  4.  
  5. Vincent HK, Taylor AG. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int J Obes. 2006;30(3):400-18. CrossRef PubMed
  6.  
  7. Afanas’ev VV, Striuk RI, Arutiunian SE, Eliseeva LV, Bychkov RA. Reactive-dystrophic processes in salivary glands (sialoadenoses) running on the background of metabolic syndrome. Stomatologiia. 2011;90(4):49-53. [Russian].
  8. Denisov AB. Salivary glands. Saliva. Moscow: RAMS Publishing House; 2003. [Russian[. Miskowiak B, Partyka M. Effects of neonatal treatment with MSG (monosodium glutamate) on hypothalamopituitary- thyroid axis in adult male rats. Histol Histopathol. 1993;8(4):731-4.
  9.  
  10. Miskowiak B, Partyka M. Effects of neonatal treatment with MSG (monosodium glutamate) on hypothalamopituitary-thyroid axis in adult male rats. Histol Histopathol. 1993;8(4):731-4.
  11. Novelli EL, Diniz YS, Galhardi CM, Ebaid GM, Rodrigues HG, Mani F et al. Antropometrical parameters and markers of obesity in rats. Lab Anim. 2007;41(1):111-19. CrossRef PubMed
  12.  
  13. Stalnaya ID, Garishvili TG. Method for determination of malondialdehyde using the thiobarbituric acid. Modern methods in biochemistry. Moscow: Medicine; 1977. p. 66-8. [Russian].
  14.  
  15. Koroliuk MA, Ivanov LI, Mayorov Y.H. Method for determining of catalase activity. Laboratornoye delo. 1988;(1):16-9. [Russian]. Berkalo LV, Bobovich OV, Bobrova NO. Methods of Clinical and experimental studies in medicine. Kaidashev IP, editor. Poltava (UA): Polimet; 2003. [Ukrainian].
  16. Berkalo LV, Bobovich OV, Bobrova NO. Methods of Clinical and experimental studies in medicine. Kaidashev IP, editor. Poltava (UA): Polimet; 2003. [Ukrainian]. 

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