Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 80-86


Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle

Fedotova IuO1, Frolova HO2

  1. Pavlov Institute of Physiology RAS, Snt Petersburg, Russia
  2. Donetsk Natioanal University, Donetsk, Ukraine
DOI: https://doi.org/10.15407/fz60.04.080

Abstract

The present work was devoted to the comparative analysis of a4в2 nicotinic acetylcholine receptors (nAChRs) in learning/ memory processes during ovary cycle assessed in adult female rats. RJR-2403 (1.0 mg/kg, i.p.), a4в2 nAChRs agonist and mecamylamine (1.0 mg/kg, i.p.), a4в2 nAChRs antagonist were injected chronically during 14 days. The processes of learning/memory were assessed in different models of learning: passive avoidance performance and Morris water maze. Chronic RJR-2403 administration to female rats improved the passive avoidance performance in proestrous and estrous as compared to the control animals. Also, RJR-2403 restored spatial learning during proestrous phases in Morris water maze, and stimulated the dynamics of spatial learning during estrous phases. On the contrary, chronic mecamylamine administration impaired non-spatial, and especially, spatial learning in females during key phases of ovary cycle. The results of the study suggest positive effect of a4в2 nAChRs stimulation in learning/ memory processes during ovary cycle in the adult female rats. Key words: RJR-2403, mecamylamine, a4в2 nAChRs, learning, ovary cycle, female rats.

Keywords: RJR-2403, mecamylamine, a4в2 nAChRs, learning,ovary cycle, female rats.

References

  1. Warren SG, Juraska JM. Spatial and nonspatial learning across the rat estrous cycle.Behav Neurosci. 1997; 2: 259-266. CrossRef  
  2. Jensen AA, Frolund B, Liljefors T, Krogsgaard-Larsen P. Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005; 48: 4705- 4745. CrossRef PubMed
  3.  
  4. Hogg RC, Raggenbass M, Bertrand D. Nicotinic acetylcholine receptors: from structure to brain function. Rev Physiol Biochem Pharmacol. 2003; 147: 1-46. CrossRef PubMed
  5.  
  6. Picciotto MR. Nicotine as a modulator of behavior: beyond the inverted. U Trends Pharmacol Sci. 2003; 24: 493-499. CrossRef  
  7. Dumas J, Hancur-Bucci C, Naylor M, Sites C, Newhouse P. Estrogen treatment effects on anticholinergic-induced cognitive dysfunction in normal postmenopausal women. Neuropsychopharmacol. 2006; 31: 2065-2078. CrossRef PubMed
  8.  
  9. Norbury R, Travis MJ, Erlandsson K, Waddington W, Ell PJ Murphy DG. Estrogen therapy and brain muscarinic receptor density in healthy females: a SPETstudy. Horm Behav. 2007; 51: 249-257. CrossRef PubMed
  10.  
  11. Pompili A, Tomaz C, Arnone B, Tavares MC, Gasbarri A. Working and reference memory across the estrous cycle of rat: a long term study in gonadally intact females. Behav Brain Res. 2010; 213: 10-18. CrossRef PubMed
  12.  
  13. Pompili A, Benedetto AA., Gasbarri A. Estrogens and memory in physiological and neuropathological conditions. Psychoneuroendocrinol. 2012; 37: 1379-1396. CrossRef PubMed
  14.  
  15. Hasselmo ME. The role of acetylcholine in learning and memory. Curr Opin Neurobiol. 2006; 16: 710-715. CrossRef PubMed PubMedCentral
  16.  
  17. Kirshenblat YaD. Workshop on Endocrinology. "Moscow;1969.
  18. Bures J, Buresova O, Huston J. Techniques and basic experiments for the study of brain and behavior. Moscow. 1991. 
  19.  
  20. Ponomarev DB, Vinogradova EP. Comparative analysis of the learning ability in Morris water test in rats with the various rate of active acquisition of the avoidance conditioned reflex. IP Pavlov J Higher Nervous Activity. 2000; 50 (6): 974-981.
  21.  
  22. Daniel JM, Fader, Spencer AJ, Dohanich AL. Estrogen enhances performance of female rats during acquisition of a radial arm maze. Horm Behav. 1997; 32: "Q.217-225.
  23.  
  24. Warren SG, Juraska JM. Spatial and nonspatial learning across the rat estrous cycle. Behav Neurosci. 1997; 2: 259-266. CrossRef  
  25. Flores CM, Rogers SW, Pabreza LA., Wolfe BB, Kellar KJ. Asubtype of nicotinic cholinergic receptor in rat brain is composed of ?i4 and ?A2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol. 1992; 41: 31-37. PubMed
  26.  

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.