Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle
Fedotova IuO1, Frolova HO2
- Pavlov Institute of Physiology RAS, Snt Petersburg, Russia
- Donetsk Natioanal University, Donetsk, Ukraine
The present work was devoted to the comparative analysis of
a4в2 nicotinic acetylcholine receptors (nAChRs) in learning/
memory processes during ovary cycle assessed in adult female
rats. RJR-2403 (1.0 mg/kg, i.p.), a4в2 nAChRs agonist and
mecamylamine (1.0 mg/kg, i.p.), a4в2 nAChRs antagonist
were injected chronically during 14 days. The processes of
learning/memory were assessed in different models of learning:
passive avoidance performance and Morris water maze.
Chronic RJR-2403 administration to female rats improved
the passive avoidance performance in proestrous and estrous
as compared to the control animals. Also, RJR-2403 restored
spatial learning during proestrous phases in Morris water maze,
and stimulated the dynamics of spatial learning during estrous
phases. On the contrary, chronic mecamylamine administration
impaired non-spatial, and especially, spatial learning in females
during key phases of ovary cycle. The results of the study suggest
positive effect of a4в2 nAChRs stimulation in learning/
memory processes during ovary cycle in the adult female rats.
Key words: RJR-2403, mecamylamine, a4в2 nAChRs, learning,
ovary cycle, female rats.
RJR-2403, mecamylamine, a4в2 nAChRs, learning,ovary cycle, female rats.
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