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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 80-86

Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle

Fedotova IuO1, Frolova HO2

  1. Pavlov Institute of Physiology RAS, Snt Petersburg, Russia
  2. Donetsk Natioanal University, Donetsk, Ukraine


The present work was devoted to the comparative analysis of a4в2 nicotinic acetylcholine receptors (nAChRs) in learning/ memory processes during ovary cycle assessed in adult female rats. RJR-2403 (1.0 mg/kg, i.p.), a4в2 nAChRs agonist and mecamylamine (1.0 mg/kg, i.p.), a4в2 nAChRs antagonist were injected chronically during 14 days. The processes of learning/memory were assessed in different models of learning: passive avoidance performance and Morris water maze. Chronic RJR-2403 administration to female rats improved the passive avoidance performance in proestrous and estrous as compared to the control animals. Also, RJR-2403 restored spatial learning during proestrous phases in Morris water maze, and stimulated the dynamics of spatial learning during estrous phases. On the contrary, chronic mecamylamine administration impaired non-spatial, and especially, spatial learning in females during key phases of ovary cycle. The results of the study suggest positive effect of a4в2 nAChRs stimulation in learning/ memory processes during ovary cycle in the adult female rats. Key words: RJR-2403, mecamylamine, a4в2 nAChRs, learning, ovary cycle, female rats.

Keywords: RJR-2403, mecamylamine, a4в2 nAChRs, learning,ovary cycle, female rats.


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