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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 56-60

The blood leptin and the activity of the system inflammatory response in patients with diabetes mellitus type 2 with different body weight and disease duration

Man'kovs'kyĭ BM, Urbanovych AM

    Lviv Medical University, Lviv, Ukraine


Recent studies focused on the adipose tissue hormones role, especially leptin as one of the basic and generalized nonspecific inflammation markers among them. Some of the major markers are IL-2, IL -6 and TNF-б, in the pathogenesis of diabetes (DM) and its complications. It is established that patients with type 2 diabetes lasting from 5 to 10 years represent the highest leptin and cytokines levels, and during this period cardiovascular complications of type 2 diabetes are formed. Also it is found that the leptin level was significantly lower in patients with normal body weight, while the levels of IL-6 and TNF-б are the highest in these patients. Obviously, the increased level of these cytokines helps to maintain a normal body weight in these patients. Despite the fact that type 2 diabetes is considered a non-autoimmune disease, it is known that for a long glucose toxicity and lipotoxicity metabolic immunosuppression occurs, which causes changes in T-cell immunity, and consequently to autoimmunity.

Keywords: diabetes mellitus, leptin, interleicin.


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