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The blood leptin and the activity of the system inflammatory response in patients with diabetes mellitus type 2 with different body weight and disease duration
Man'kovs'kyĭ BM, Urbanovych AM
Lviv Medical University, Lviv, Ukraine
DOI: https://doi.org/10.15407/fz60.04.056
Abstract
Recent studies focused on the adipose tissue hormones role,
especially leptin as one of the basic and generalized nonspecific
inflammation markers among them. Some of the major markers
are IL-2, IL -6 and TNF-б, in the pathogenesis of diabetes
(DM) and its complications. It is established that patients
with type 2 diabetes lasting from 5 to 10 years represent the
highest leptin and cytokines levels, and during this period
cardiovascular complications of type 2 diabetes are formed.
Also it is found that the leptin level was significantly lower
in patients with normal body weight, while the levels of IL-6
and TNF-б are the highest in these patients. Obviously, the
increased level of these cytokines helps to maintain a normal
body weight in these patients. Despite the fact that type 2
diabetes is considered a non-autoimmune disease, it is known
that for a long glucose toxicity and lipotoxicity metabolic
immunosuppression occurs, which causes changes in T-cell
immunity, and consequently to autoimmunity.
Keywords:
diabetes mellitus, leptin, interleicin.
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