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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 50-55

Cellular and humoral immunity in rats with atopic dermatitis

Berezniakova AI, Cheremisina VF, Zhemela OD.

    National University of Pharmacy, Kharkiv, Ukraine


We studied indicators of systemic and local immunity in rats with allergic dermatitis (Ig A, E, G, M, CIC, CD3, CD4, CD8, SD19, SD56). In rats with allergic dermatitis on the local level, the most active is humoral immunity. One of the pathogenesis of atopic dermatitis is an increased content of circulating immune complexes in the blood and decreased T-helper in a total amount of T- lymphocytes. An informative index with a high level of correlation is the IgE level, confirming the advisability of its determination in blood plasma in acute dermatitis to characterize lymphocyte apoptosis markers and prognosis of the disease. An established negative correlation between the concentrations of SD95-marker of apoptosis and the IgE level in healthy and sick animals may point for involvement of apoptosis in the regulation of the total IgE.

Keywords: allergic dermatitis, immunoglobulin, circulatingimmune complexes.


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