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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 30-39

The changes of processes of free radical oxidation of lipids and proteins, antioxidant defence in rats with hypofunction of the thyroid gland in conditions of iodine and copper deficiency

Voronych-Semchenko NM, Huranych TV

    Ivano-Frankivsk Medical University, Ivano-Frankivsk, Ukraine


Thyroid status, copper balance, correlation of processes of peroxide oxidation of lipids (POL), proteins (POP), antioxidant defence (AOD) were examined in experiments on rats with hypofunction of thyroid gland under iodine monodeficit (HTGI) and combined iodine and copper deficit (HTGI+Cu). It was determined that a combined deficit of microelements is accompanied by a distribution of copper content between different tissues (increase in red blood cell mass and cerebrum, decrease in myocardium), essential changes of indexes of hypotalamo-hypophysis-thyroid axis, oxygen-dependent metabolism, antiradical defense, exacerbating the effects of negative influence of each of them on organism. It was established that HTGI+Cu causes a suppression of oxygendependent processes. In thyroid gland, it is shown a decrease of content of dyenic conjugates (DC) by 69,70% , of TBAreacting products (TBA-RP) by 47,72% in diencephalon, the volume of modified proteins (VMP) - by 37,10-98,98% in the tissues of diencephalons. The results obtained let us to suggest a pivotal role of microelement dysbalance and metabolic mechanisms in pathogenesis of cardiological pathology under thyroid dysfunction. The development of HTGI +Cu exhausts the resources of AOD: decreases the activity of catalase (on 47,05%), superoxide dismutase (on 33,13%), ceruloplasmine (on 33,93%) and saturation of transferrin with iron (on 56,76%) against the background of selective rise in the activity of glutationreductase (in 2,8 time) in comparison with the control data. The long-term disturbances of antyoxidative defence can be the reason of manifestation of oxygendependent processes and the development of pathological changes in separate physiological systems of organism. Key words: hypofunction of thyroid gland, microelement imbalance, freeradical oxidation of lipids, peroxidative oxidation of proteins, antioxidant system.

Keywords: hypofunction of thyroid gland, microelement imbalance,freeradical oxidation of lipids, peroxidative oxidationof proteins, antioxidant system.


  1. Honcharova OA. Gender peculiarities of thyroid homeostasis in patients of different age with autoimmune thyroiditis. Problems of Aging and Longevity. 2012; 21(3):336-42.
  3. Moskalenko RA. Morphogenesis of thyroid gland in conditions of induced microelement deficiency and correction of such influence by glutargin. Herald of Sumy State University. 2010;1:27-36.
  5. Marsakova NV, Esypenko BE. Metabolism of iodine, carbohydrates and proteins in rats in deficiency of iodine, copper and cobalt. Physiologic J. 1990;36:51-9.
  7. Farkhutdinova L. Role of microelements in development of pathology of thyroid gland. Physician. 2006;3:43-4.
  9. Fal'fushyns'ka HI, Hnatyshyna LL, Osadchuk DV. Metallic depot function and antioxidant features of thyroid gland in humans with iodine deficiency nodular colloid goiter. Ukr Biochem J. 2011;83(6):92-7.
  11. Oribko IB. Biological role of copper in oxidation reducing processes in the organism. News of Dentistry. 2000;2:61-2.
  13. Brent GA. The molecular basis of the thyroid hormone action. The New Engl J of Medicine. 1994; 331:847-53. CrossRef PubMed
  15. Anikeeva TV, Maksimova LY, Sinyachenko OV. Content of copper and zinc in hair and blood in ischemic and chronic rheumatic heart diseases. Ukr Med Almanac. 2009;1:7-9.
  17. Anikeeva TV, Maksimova LY, Sinyachenko OV. Content of copper and zinc in hair and blood in ischemic and chronic rheumatic heart diseases. Ukr Med Almanac. 2009;1:7-9.
  19. Dubinina EE, Morozova MH, Leonova NV. Oxidative modification of blood plasma proteins of patients with psychological disorders: depression, depersonalization. Issues of Med Chemistry. 2000;4:7-9.
  21. Lezhenko HO, Pashkova OE, Kamenschyk AV. State of activity of peroxidation of proteins in children and patients with diabetes mellitus in dynamics of disease. Clin Pediatrics. 2008;6:51-6.
  23. Topchyy II, Kirienko AN, Bondar' TN. Lipid peroxidation and metabolism of nitric oxide in patients with chronic kidney disease in dynamics of treatment. Ukr J Nephrol and Dialisis. 2012;1:S.3-8.
  25. Bezrukov OF, Grygor'ev PE. Role of concentration of copper containing compounds in diet and the incidence of thyroid pathology. Tavrian Medical and Biological Newspaper. 2010;13(4):11-3.
  27. Krasnokuts'kyy SV. Vitamin E in prophylaxis and treatment of states linked with the activation lipid peroxidation. Circulation and Hemostasis (Gift). 2010;1- 2:115-20.
  29. Martinez-Galan JR, Pedraza P., Santacana M. Early effect of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. J Clin Invest. 1997; 99:2701-2709. CrossRef PubMed PubMedCentral
  31. Charnosh SM. Comparative characteristics of three experimental models of hypothyroidism. Herald of Scientific Researches. 2007;2:113-5.
  33. Yamamoto M, Aklyama C, Aikawa H. D-penicillamine – induced copper deficiency in suckling mice: neurogical abnormalities and brain mitochondrial enzyme activities. Developmental Brain Research. 1990;55(1):51-5. CrossRef  
  34. Barysheva ES. Role of microelements in functional and structural homeostasis of thyroid gland. Physician. 2010; 7(37):1-12.
  36. Dunn JT, Grutchfield HE, Gutekunst R. Two simple methods for measuring iodine in urine. Thyroid. 1993;3(2):119-23. CrossRef PubMed
  38. Kulimbetov MT, Rashytov MM, Saatov TS. Modeling of experimental hypothyroidism caused by natural iodine chronic nutrient deficiency. Int Endocr J. 2009; 2(20):22-27.
  40. Romanyuk AM, Moskalenko. Peculiarities of metabolism of microelements in thyroid gland in proliferative diseases in conditions of influence of salts of heavy metals. Herald of Sumy State University. 2007;1:9-13.
  42. Panishyna NG, Yurzhenko NM, Briuzgina TS Status of lipid peroxidation in experimental hypothyroidism. BMJ. 2008;1:104-106.
  44. Neyko EM. Microelements in medicine. Contribution of scientists of Ivano-Frankivsk state medical university. Galician Medical J. 2008;2:5-8.
  46. Kryuk YY, Makhneva AV, Zolotukhin SE. Peculiarities of manifestation of oxidative stress in hypothyroidism of different degree of severity in an experiment. Pathol. 2011;8(2):62-5.
  48. Kul'chyts'kyy OK, Potapenko RI, Novikova SM, Burchyns'ka MK. Activity of the processes of lipid peroxidation and oxidative modification of proteins inrats of different age in conditions of action of intermittent hypobaric hypoxia. Problems of Aging and Longevity. 2011;20(3):291-301.
  50. Pinyazhko RO, Hzhehots'kyy MR. Changes of oxidative metabolism in conditions of experimental esophagitis on the background of hypothyroid dishomeostasis and correction by melatonin. AML. 2011;1:77-81.
  52. Drobins'ka OV, Hayda LM, Dvorschenko KO. State of system of lipid peroxidation and antioxidant defense in parietal cells in conditions of development of experimental chronic atrophic gastritis. Ukr Biochemical J. 2010;82(5):85-91.

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