The functional state of the kidneys after adenosine triphosphate-sensitive potassium channels activation in experimental acute hypoxia
Hozhenko AI1, Filipets' ND2
- State Enterprise «Ukrainian Research Institute of TransportMedicine» of Ukrainian Ministry of Health Care, Odessa, Ukraine
- Bukovinian State Medical University, Chernivtsi, Ukraine
In the experiments on non-linear white rats with the model of
acute hypoxia we have studied the changes of the functional
state of kidneys after a single intraventricular administration
of the original fluorine-containing KATP-sensitive potassium
channels activator flocalin at the dose of 5 mg/kg on the
background of induced water load. It has been shown that
under the influence of prohypoxic factors: sodium nitrite
(50 mg/kg, subcutaneously) and dinitrophenol (3 mg/kg,
intraperitoneal) flocalin activates volume-regulating, ionregulating
and excretory functions of kidneys. Renal effects
after activation of KATP-sensitive potassium channels in the
rats with histohemic hypoxia were induced by the changes of
tubular and predominantly glomerular processes. The increase
of glomerular filtration rate, restoration of volatile distal
reabsorption of potassium channels, decrease of sodium loss
with urine, decrease of proteinuria after a single administration
of flocalin under conditions of acute hypoxia complement
the range of protective effects of KATP-sensitive potassium
channels activator flocalin.
Key words: kidneys, adenosine triphosphate sensitive
potassium channels, acute hypoxia, flocalin.
kidneys, adenosine triphosphate sensitivepotassium channels, acute hypoxia, flocalin.
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