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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 22-29


The functional state of the kidneys after adenosine triphosphate-sensitive potassium channels activation in experimental acute hypoxia

Hozhenko AI1, Filipets' ND2

  1. State Enterprise «Ukrainian Research Institute of TransportMedicine» of Ukrainian Ministry of Health Care, Odessa, Ukraine
  2. Bukovinian State Medical University, Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz60.04.022

Abstract

In the experiments on non-linear white rats with the model of acute hypoxia we have studied the changes of the functional state of kidneys after a single intraventricular administration of the original fluorine-containing KATP-sensitive potassium channels activator flocalin at the dose of 5 mg/kg on the background of induced water load. It has been shown that under the influence of prohypoxic factors: sodium nitrite (50 mg/kg, subcutaneously) and dinitrophenol (3 mg/kg, intraperitoneal) flocalin activates volume-regulating, ionregulating and excretory functions of kidneys. Renal effects after activation of KATP-sensitive potassium channels in the rats with histohemic hypoxia were induced by the changes of tubular and predominantly glomerular processes. The increase of glomerular filtration rate, restoration of volatile distal reabsorption of potassium channels, decrease of sodium loss with urine, decrease of proteinuria after a single administration of flocalin under conditions of acute hypoxia complement the range of protective effects of KATP-sensitive potassium channels activator flocalin. Key words: kidneys, adenosine triphosphate sensitive potassium channels, acute hypoxia, flocalin.

Keywords: kidneys, adenosine triphosphate sensitivepotassium channels, acute hypoxia, flocalin.

References

  1. Moibenko AA, Strutynskyi RB, Yagupolskii LM, Mohort MA, Shalamai AS. Organization of industrial production of Flokalin – new myotropic spasmolytic and cardioprotektor. Science and Innovation. 2009; 5(1): 80-84.
  2.  
  3. Strutynskyi RB, Kotsuruba AV, Neshcheret AP, Shysh AN, Rovenets RA, Moibenko AA. Cardioprotective Effects of ATP-Sensitive Potassium Channels Activation in Experiments in Vivo: Influence on Biochemical Parameters of Blood Following Ishemia-Reperfusion of Myocardium. Int J Phys Pathophys. 2010; 1(4): 305-313. CrossRef  
  4. Strutynskyi RB, Neshcheret AP, Tumanovska LV, Rovenets RA, Moibenko AA. Cardioprotective effects of flocalin in vivo experiments: influence of the hemodynamic and on the damage of myocardium under ishemia-reperfusion. Int Phys Pathophys. 2010; 1(3): 211-218. CrossRef  
  5. Voitychuk OI, Strutynskyi RB, Yagupolskii LM, Tinker A, Moibenko OO, Shuba YM. Sarcolemmal cardiac KATP channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue flocalin. Brit J Pharmacol. 2011; 162(3): 701-711. CrossRef PubMed PubMedCentral
  6.  
  7. Shieh C, Coghlan M, Sullivan J, Gopalakrishnan M. Potassium Channels: Molecular Defects, Diseases and Therapeutic Opportunities. Pharm. Rew. 2000; 52(4): 557-594.
  8.  
  9. Gozhenko AI, Filipets ND. The renotropic effects of adenosine triphosphate-sensitive potassium channel activation depending on the functional state of kidneys in rats. Nephrology. 2013; 17(2): 87-90.
  10.  
  11. Filipets ND, Filipets OO. The state of homeostatic function of the kidneys after repeated activation of potassium channels with flokalin at salt load. Medicine of Ukraine. 2012; (1-2): 66-69.
  12.  
  13. Filipets ND. The effect of ATP-sensitive potassium channels activator flocalin on acid-regulatory function of kidneys under conditions of load with 0,45% solution of sodium chloride. Tavr Med-Biol Vestnik. 2012; 15 (3 Pt 1): 358-36.
  14.  
  15. Putilina FYe, Eschenko ND. Effect of hypoxia and 2,4-dinitrophenol on lactate dehydrogenase activity in brain, liver, kidneys. Issues Med Chem. 1971; 17(2): 161-165.
  16.  
  17. Berhyn YeB, Ivanov YuI. Methods of experimentally studies of kidney and water-salt metabolism. Barnaul: Book publishing house of Altaysk; 1972: 47-79.
  18.  
  19. Mikheeva AI, Bogodarova IA. Methods of determination of the total protein in the urine on the FEC-H-56. Laboratory Business. 1969; (7): 441-442.
  20.  
  21. Gozhenko AI, Gozhenko YeA. Functional renal reserve in renal physiology and pathology. Bukov Med Herald. 2012; 16(3 Pt 2): 18-25.
  22.  
  23. Strutynskyi RB. The vazodilatatory effects of flokalin, a fluorine-containing KATP channel opener. Fiz Zh. 2010; 56(4): 59-65.
  24.  
  25. Boychuk TN, Rohovoy YuYe, Popovich GB. Pathophysiology of hepatorenal syndrome in hemic hypoxia. Chernivtsi: Medical University; 2012: 123-151.
  26.  
  27. Filipets ND, Olenovych OA, Filipets OO, Kmet OG. Influence of flocalin on the indicies of proteolytic and fibrinolytic activity at the initial stage of experimental acute renal failure. Ukr J Nephrol and Dial. 2012; (3 Suppl 1): 41-43.

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