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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(4): 22-29

The functional state of the kidneys after adenosine triphosphate-sensitive potassium channels activation in experimental acute hypoxia

Hozhenko AI1, Filipets' ND2

  1. State Enterprise «Ukrainian Research Institute of TransportMedicine» of Ukrainian Ministry of Health Care, Odessa, Ukraine
  2. Bukovinian State Medical University, Chernivtsi, Ukraine
DOI: https://doi.org/10.15407/fz60.04.022


Abstract

In the experiments on non-linear white rats with the model of acute hypoxia we have studied the changes of the functional state of kidneys after a single intraventricular administration of the original fluorine-containing KATP-sensitive potassium channels activator flocalin at the dose of 5 mg/kg on the background of induced water load. It has been shown that under the influence of prohypoxic factors: sodium nitrite (50 mg/kg, subcutaneously) and dinitrophenol (3 mg/kg, intraperitoneal) flocalin activates volume-regulating, ionregulating and excretory functions of kidneys. Renal effects after activation of KATP-sensitive potassium channels in the rats with histohemic hypoxia were induced by the changes of tubular and predominantly glomerular processes. The increase of glomerular filtration rate, restoration of volatile distal reabsorption of potassium channels, decrease of sodium loss with urine, decrease of proteinuria after a single administration of flocalin under conditions of acute hypoxia complement the range of protective effects of KATP-sensitive potassium channels activator flocalin. Key words: kidneys, adenosine triphosphate sensitive potassium channels, acute hypoxia, flocalin.

Keywords: kidneys, adenosine triphosphate sensitivepotassium channels, acute hypoxia, flocalin.

Full text: (PDF, in Ukrainian)

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