The changes of the motor function of the stomach and the colon under the action of the nanocrystalline cerium dioxide
Iefimenko OIu1, Savchenko IuO1, Falalieieva TM1, Berehova TV1, Shcherbakov OB4, Ivanov VK4, Zholobak NM2, Maliukin IuV5, Spivak MIa2,3
- Taras Shevchenko National University of Kyiv;
- Danylo Zaboloty Institute of Microbiology and Virology National Academy of Science of Ukraine;
- Company Diaprof, Ukraine
- Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
- Institute for Scintillation Materials National Academy of Science of Ukraine
DOI: https://doi.org/10.15407/fz60.03.067

Abstract
We investigated the effect of nanocrystalline cerium dioxide
on parameters of spontaneous and stimulated motility of the
stomach and colon in rats. It was found that administration
of nanocrystalline cerium dioxide for 10 days increased the
amplitude of contractions of stimulated motility in the stomach
by 33,0±2,4 % and the frequency of contractions of the colon
О.Ю. Єфіменко, Ю.О. Савченко, Т.М. Фалалєєва, Т.В. Берегова, О.Б. Щербаков, В.К. Іванов, Н.М. Жолобак, Ю.В. Малюкин, М.Я. Співак
74 ISSN 0201-8489 Фізіол. журн., 2014, Т. 60, № 3
by 80,3±7,5 %. In this group, the introduction of carbachol
also increased the frequency of the contractions by 274,0±
22,9 %, compared to the control group. The administration of
nanocrystalline cerium dioxide increased the index of motor
activity of spontaneous and stimulated motility of the stomach
by 19,8±1,4 and 14,5±9,0 %, respectively. In the colon, the motor
activity increased by 14,3±1,1 and 11,1±0,8 %, respectively.
We also found that the nanocrystalline cerium dioxide rebuilt
morphological condition of the mucous of the colon.
Keywords:
nanocrystalline cerium dioxide, motor functionof the stomach and colon.
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