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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 67-74

The changes of the motor function of the stomach and the colon under the action of the nanocrystalline cerium dioxide

Iefimenko OIu1, Savchenko IuO1, Falalieieva TM1, Berehova TV1, Shcherbakov OB4, Ivanov VK4, Zholobak NM2, Maliukin IuV5, Spivak MIa2,3

  1. Taras Shevchenko National University of Kyiv;
  2. Danylo Zaboloty Institute of Microbiology and Virology National Academy of Science of Ukraine;
  3. Company Diaprof, Ukraine
  4. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
  5. Institute for Scintillation Materials National Academy of Science of Ukraine
DOI: https://doi.org/10.15407/fz60.03.067


Abstract

We investigated the effect of nanocrystalline cerium dioxide on parameters of spontaneous and stimulated motility of the stomach and colon in rats. It was found that administration of nanocrystalline cerium dioxide for 10 days increased the amplitude of contractions of stimulated motility in the stomach by 33,0±2,4 % and the frequency of contractions of the colon О.Ю. Єфіменко, Ю.О. Савченко, Т.М. Фалалєєва, Т.В. Берегова, О.Б. Щербаков, В.К. Іванов, Н.М. Жолобак, Ю.В. Малюкин, М.Я. Співак 74 ISSN 0201-8489 Фізіол. журн., 2014, Т. 60, № 3 by 80,3±7,5 %. In this group, the introduction of carbachol also increased the frequency of the contractions by 274,0± 22,9 %, compared to the control group. The administration of nanocrystalline cerium dioxide increased the index of motor activity of spontaneous and stimulated motility of the stomach by 19,8±1,4 and 14,5±9,0 %, respectively. In the colon, the motor activity increased by 14,3±1,1 and 11,1±0,8 %, respectively. We also found that the nanocrystalline cerium dioxide rebuilt morphological condition of the mucous of the colon.

Keywords: nanocrystalline cerium dioxide, motor functionof the stomach and colon.

Full text: (PDF, in Ukrainian)

References

  1. Chernyavskiy V.V. Possibilities of modern prokinetic correction gastrointestinal motility. Vnytrennya Med. 2008;1(7): 7-9 [Russian].
    2.  
  2. Shvec N.I., Benca TM. Dysmotility syndrome of the upper gastrointestinal tract in the practice of the therapist: diagnosis and treatment. Newspaper «News of medicine and pharmacy» Gastroenerology. 2010; 323:2-3 [Russian].
    3.  
  3. O'Mahony D, O'Leary P, Quigley EM. Aging and intestinal motility: a review of factors that affect intestinal motility in the aged. Drugs Aging. 2002; 19(7):515-27. CrossRef PubMed
    4.  
  4. Cardin F, Minicuci N, Droghi AT, Inelmen EM, SergiG, Terranova O. Constipation in the acutely hospitalized older patients. Arch Gerontol Geriatr. 2010;May- Jun;50(3):277-81. CrossRef PubMed
    5.  
  5. Dehghani SM, Basiratnia M, Matin M, Hamidpour L, Haghighat M, Imanieh MH. Urinary tract infection and enuresisin children with chronic functional constipation. Iran J Kidney Dis.2013; 7(5):363-6. PubMed
    6.  
  6. Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol. 2005; Apr; 100(4):936-71. CrossRef PubMed
    7.  
  7. Malcoch AV, Belmer SV. Intestinal microflora and the value of prebiotics for its function. Lechaschiy vrach. 2006;4:60-5 [Russian].
    8.  
  8. Prasad RGSV, Davan R, Jothi S, Phana AR, Raju D.B. Cerium oxide nanoparticles protects gastrointestinal mucosa fromethanol induced gastric ulcerinin-vivo animal model. Nano Biomed Eng. 2013;5 (1):46-49. CrossRef  
  9. Babenko LP, Zholobak NM, Shcherbakov AB, Voychuk SI, Lazarenko LM, Spivak MY. Antibacterial activity of cerium colloids against opportunistic microorganisms in vitro. Mikrobiol Z. 2012; May-Jun;74(3):54-62. PubMed
    10.  
  10. Zholobak NM, Zhyravskya T.K, Kachmarskya II. Efficacy of colloidal nanoparticles of cerium and L.bulgaricus in the mouse. The matheriasl of confer. «Dovkillia ta zdorovya», Ternopil; 14-16 April 2009: 32 [Russian].
    11.  
  11. Myrzin O.B. European Convention for the Protection of Vertebrate Animals used for experimental and other scientific purposes. Dnipropetrovsk; 2004 [Russian].
    12.  
  12. Zadori ZS, Feher A, Al-Khrasani M, Lacko E, Toth VE, Brancati SB, et al. Imidazoline versus alphaadrenoceptors in the control of gastric motility in mice. Eur J Pharmacol. 2013; 705(1-3): 61-67. CrossRef PubMed
    13.  
  13. Ivanova OS, Shekynova TO, Ivanov VK, Scherbakov AB, Popov AL. One-step synthesis of colloidal solutions of cerium dioxide for biomedical applications. Dokl.Akadem. nayk. 2011; (437) 5:638-41 [Russian].
    14.  
  14. Tyurin Yu.N. Distribution associated with normal. M.: Infra*M. 1998 [Russian].
    15.  
  15. Abalo R, Vera G, Rivera AJ, Martin MI. Age-related changes in the gastrointestinal tract: a functional and immunohistochemical study in guinea-pig ileum. Life Sci. 2007;80(26):2436-45. CrossRef PubMed
    16.  
  16. Christian Breuer, Jun Oh, Gerhard J Molderings, Michael Schemann. Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations. World J Gastroenterol. 2010;16(34):4363-66. CrossRef PubMed PubMedCentral
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