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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 67-74

The changes of the motor function of the stomach and the colon under the action of the nanocrystalline cerium dioxide

Iefimenko OIu1, Savchenko IuO1, Falalieieva TM1, Berehova TV1, Shcherbakov OB4, Ivanov VK4, Zholobak NM2, Maliukin IuV5, Spivak MIa2,3

  1. Taras Shevchenko National University of Kyiv;
  2. Danylo Zaboloty Institute of Microbiology and Virology National Academy of Science of Ukraine;
  3. Company Diaprof, Ukraine
  4. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
  5. Institute for Scintillation Materials National Academy of Science of Ukraine


We investigated the effect of nanocrystalline cerium dioxide on parameters of spontaneous and stimulated motility of the stomach and colon in rats. It was found that administration of nanocrystalline cerium dioxide for 10 days increased the amplitude of contractions of stimulated motility in the stomach by 33,0±2,4 % and the frequency of contractions of the colon О.Ю. Єфіменко, Ю.О. Савченко, Т.М. Фалалєєва, Т.В. Берегова, О.Б. Щербаков, В.К. Іванов, Н.М. Жолобак, Ю.В. Малюкин, М.Я. Співак 74 ISSN 0201-8489 Фізіол. журн., 2014, Т. 60, № 3 by 80,3±7,5 %. In this group, the introduction of carbachol also increased the frequency of the contractions by 274,0± 22,9 %, compared to the control group. The administration of nanocrystalline cerium dioxide increased the index of motor activity of spontaneous and stimulated motility of the stomach by 19,8±1,4 and 14,5±9,0 %, respectively. In the colon, the motor activity increased by 14,3±1,1 and 11,1±0,8 %, respectively. We also found that the nanocrystalline cerium dioxide rebuilt morphological condition of the mucous of the colon.

Keywords: nanocrystalline cerium dioxide, motor functionof the stomach and colon.


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