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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2001; 47(3): 19-25


Cgmp-independent effect of nitric oxide on contractility and intracellularcalcium level of rat tail artery vascular smooth muscles

A.I.solovyov, V.V.legeN.kyy, S.M.zelensky, O.O.moibenko, O.V.stefanov

    Institute of pharmacology and toxicology, Academy of medical sciences of Ukraine,Kiev; Bogomoletz Institute of Physiology, National Academy of Ukraine, Kiev


Abstract

The effects of nitric oxide (NO, 10-6 M) on contractility and intracellular calcium level ([Na2+].) of rat tail artery smooth muscles in control and under inhibition of soluble guanylate cyclase (sGC) with 6-anilino-5,8-quinolinedione (LY83583, 10-6 M) are investigated. NO-induced relaxations of vascular smooth muscles comprised 61,01 ± 5,56% of maximum induced amplitude of K+-contracture, and decreases in [Ca2+]i comprised 66,35 ± 11,33%. Under the inhibition of sGC with LY83583 NO-induced relaxations of vascular smooth muscles comprised 29,41 ± 5,17% of maximum induced amplitude of K+-contracture, and decreases in [Ca2+]i comprised 53,68 ± 16,93%. Thus, cGMP-independent relaxation of vascular smooth muscle and decrease in [Na2+]. of rat tail artery is confirmed.

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