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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 60-66

Effects of 2-(2-hydroxyphenoxy) acetyl-L-prolinate sodium on antioxidant defense system of the gastric mucosa of rats under conditions of stress action

Hadiliia OP, Tymoshenko MO, Dvorshchenko KO, Ostapchenko LI, Vereshchaka VV

    Taras Shevchenko National University, Kyiv, Ukraine


We investigated the preventive effect of low molecular weight organic compound 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium on erosive and ulcerative lesions in the gastric mucosa caused by stress. It was established that prophylactic administration of this substance to rats at a dose of 1 mg/kg reduced the lesion area by 56.7 %. 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium efficiently restored the impaired pro-/antioxidative balance in the gastric mucosa of rats under stress: the content of diene conjugates was reduced by 1.24 times, TBA-active products reduced by 1.31 times, Schiff’s bases reduced by 1.28 times. This effect was accompanied by increased activities of the superoxide dismutase, catalase and of glutathione system.

Keywords: stress, gastric mucosa lesions, pro/antioxidantbalance, 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium.


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