Effects of 2-(2-hydroxyphenoxy) acetyl-L-prolinate sodium on antioxidant defense system of the gastric mucosa of rats under conditions of stress action
Hadiliia OP, Tymoshenko MO, Dvorshchenko KO, Ostapchenko LI, Vereshchaka VV
Taras Shevchenko National University, Kyiv, Ukraine
We investigated the preventive effect of low molecular weight
organic compound 2-(2-hydroxyphenoxy) acetyl-L-prolinat
sodium on erosive and ulcerative lesions in the gastric mucosa
caused by stress. It was established that prophylactic
administration of this substance to rats at a dose of 1 mg/kg
reduced the lesion area by 56.7 %. 2-(2-hydroxyphenoxy)
acetyl-L-prolinat sodium efficiently restored the impaired
pro-/antioxidative balance in the gastric mucosa of rats under
stress: the content of diene conjugates was reduced by 1.24
times, TBA-active products reduced by 1.31 times, Schiff’s
bases reduced by 1.28 times. This effect was accompanied by
increased activities of the superoxide dismutase, catalase and
of glutathione system.
stress, gastric mucosa lesions, pro/antioxidantbalance, 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium.
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