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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 46-53


The influence of amylin on the bile acid spectrum in rats

Vasheka IP, Vesel'skyĭ SP, Horenko ZA, Hrinchenko OA, Karbovs'ka LS, Makarchuk MIu

    Taras Shevchenko National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.03.046

Abstract

In acute experiments on the rats with cannulated common biliary duct, the influence of amylin on the level of bile secretion and bile acids spectrum was investigated. It was shown that subcutaneous administration of amylin at the dose 1 mg/kg body weight doesn’t affect the volume of secreted bile. Under these conditions, the concentration of taurocholic acid was increased and the concentration of tauroconjugates of chenodeoxycholic and deoxycholic acids was decreased in the bile. At the same time, the concentration of glycocholates remained constant and of unconjugated bile acids was decreased. This redistribution of bile acids spectrum leads to an increase in the coefficient of conjugation. Amylin changes the ratio of trygydroxy- and dygydroxycholates in secreted bile leading to an increase in the coefficient of hydroxylation. These results suggest that amylin enhances the processes of conjugation and hydroxylation of bile acids in hepatocytes that results in improvement of detergent properties of the bile, particularly, the ability of the bile to maintain the cholesterol in dissolved state. At the lowest effective dose, amylin does not alter the concentration of glucose in the blood.

Keywords: amylin, bile formation, taurocholates, glycocholates,unconjugates bile acids.

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