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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 32-37

The influence of omega-3 polyunsaturated fatty acids on the expression of enzymes of the prooxidant and antioxidant systems in the rat liver

Maksymchuk OV

    Institute of Molecular Biology and Genetics, NAS of Ukraine, Kyiv, Ukraine


Omega-3 polyunsaturated fatty acids (PUFAs) are involved in the regulation of many physiological processes by modulating the activity of transcription factors. However, the properties of the compounds to influence the pro - antioxidant processes in liver are poorly investigated. We aimed to study the changes in expression of cytochrome P450 2E1 (CYP2E1) with a strong prooxidant activity, and heme oxygenase 1 (HO-1), which is characterized by anti-apoptotic and anti-inflammatory properties, and evaluation of the activity of antioxidant enzymes in the liver of experimental animals under the action of omega-3 PUFAs. It was shown a significant increase in cytochrome P450 2E1 and heme oxygenase 1 expression in the liver of rats treated with the omega-3 PUFAs (per os, daily for 4 weeks). At the same time, there were no changes in the activity of antioxidant enzymes - superoxide dismutase and catalase. Probably an increase of the level of cytochrome P450 2E1 leads to induction of expression of enzymes with cytoprotective properties, such as heme oxygenase-1, by ROS-dependent activation of certain signaling pathways. Such CYP2E1-dependent activation of expression of HO-1 is one of the possible mechanisms of manifestation of antioxidant, antiapoptotic and anti-inflammatory properties of omega-3 PUFAs.

Keywords: Cytochrome P450 2E1, omega-3 polyunsaturatedfatty acids, heme oxygenase-1, catalase, superoxide dismutase


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