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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 27-31

The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension

Pashevin DO, Honcharov SV, Tumanovs'ka LV, Dosenko VIe, Moĭbenko OO.

    Bogomoletz Institute of Physiology, National Academy Sciences of Ukraine, Kyiv, Ukraine


The changes in the activity of intracellular proteolytic systems are important mechanisms in the damage of blood vessels walls and arterial hypertension. Tripeptidyl peptidase II (TPP II) is one of the giant intracellular protease that is still poorly known. It fulfils hydrolysis of peptides, coming from proteasomal proteolysis. Modeling of cholesterol atherosclerosis in rabbits (1 % of cholesterol in diet for 2 month) results in the significant decrease of TPP II activity in aorta tissues. This diet in spontaneously hypertensive rats (SHR) leads to a decrease of TPP II activity in aorta tissues (on 50%, Р<0,05) but has no influence on the activity of TPP II in Wistar rats. Application of Quercetin prevents the inhibition of TPP II activity in aorta tissues of rabbits and SHR at experimental hypercholesterolemia. The data received show that changes in the activity of TPP II play an important role in pathogenesis of blood vessels wall in atherosclerosis and arterial hypertension

Keywords: Tripeptidyl peptidase II, cholesterol atherosclerosis,arterial hypertension.


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