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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(3): 18-26

Pathological remodeling of myocardium in spontaneous hypertensive rats with experimental diabetes mellitus: the role of mitochondrial dysfunction

Kolesnyk IuM, Kolesnyk MIu, Abramov AV.

    Zaporizhzhya State Medical University, Zaporizhzhya, Ukraine


I collagen was investigated in myocardium of normotensive Wistar rats and spontaneous hypertensive rats with and without experimental diabetes. The Ca2+-induced mitochondrial permeability transition pore was assessed in mitochondria isolated from rat hearts. The contents of cardiotrophin-1, annexin V and type I collagen in spontaneous hypertensive rats with diabetes were higher compared with that detected in the groups of normotensive rats and rats with diabetes. The cardiac titin level was 27 % lower in animals with hypertension and diabetes compared to spontaneous hypertensive rats without diabetes. The changes of cardiotrophin-1, annexin V, titin and type I collagen expression were associated with higher sensitivity of mitochondrial pore to Ca2+ in myocardium of spontaneous hypertensive rats with diabetes.

Keywords: cardiotrophin-1, annexin V, titin, type I collagen,mitochondrial pore, myocardium, rats, hypertension, diabetesmellitus.


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