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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(2): 63-69


The effect of probiotic therapy on development of experimental obesity in rats caused by monosodium glutamate

Savcheniuk OA1, Virchenko OV1, Falalieieva TM1, Beregova TV1, Babenko LP1, Lazarenko LM2, Spivak MIa2

  1. Taras Shevchenko National University, Kyiv, Ukraine
  2. Zabolotnyi Institute of microbiology and virusology NAS ofUkraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.02.063

Abstract

The effect of a mixture of probiotic strains (2:1:1 Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL, Bifidobacterium animalis VKB) on the development of experimental obesity in rats induced by neonatal administration of monosodium glutamate has been studied. It was shown that in rats of 4 months age, the injection of monosodium glutamate (4 mg/g) at 2, 4, 6, 8, 10 days after birth elicited abdominal obesity and metabolic syndrome. An intermittent administration of a probiotic mixture to rats treated with monosodium prevented the development of obesity. In the group of rats treated with probiotics, anthropometric parameters (weight and body length, Lee index, body mass index) did not differ from the level of intact rats. Visceral fat mass was decreased by probiotics by 38,5 % (P<0,05) compared to rats treated with water. Probiotics improved lipid metabolism: reduced the level of VLDL by 32,2 % (P<0,05), the level of LDL by 30,6 % (P<0,05), increased HDL by 25,7 % (P<0,05) compared to obese control rats. Probiotic strains restored the secretion of adipocytes hormones (leptin and adiponectin) to the normal level of intact animals. The results show the effectiveness of probiotics for the prevention of obesity.

Keywords: obesity, MSG, probiotics

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