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The impact of modulators of nitric oxide synthesis on biochemical indices of liver in rats
O.M. Oleshchuk
Horbachevsky Ternopil State Medical University, Ukraine
DOI: https://doi.org/10.15407/fz60.02.057
Abstract
In experiments on white male rats it was shown that repeated
administrations of nitric oxide precursors L-arginine and
L-arginine L-glutamate do not alter the activity of cytolysis
enzymes, reduce lipid peroxidation that correlates with indices
of antioxidant protection, increase enzymatic activity in
mitochondria and reduce endotoxemia. NO-synthase blockade
by L-NAME increases endotoxemia, inhibits detoxification
process in the liver, reduces the activity of electron transport
enzymes in mitochondria, activation of lipids peroxodation
reducing protective reserves of antioxidant system that is accompanied
by low levels of NO2 ЎҐ in blood and liver.
Keywords:
nitric oxide, liver, L-arginine, L-arginine Lglutamate,L-NAME.
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