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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(2): 57-62

The impact of modulators of nitric oxide synthesis on biochemical indices of liver in rats

O.M. Oleshchuk

    Horbachevsky Ternopil State Medical University, Ukraine


In experiments on white male rats it was shown that repeated administrations of nitric oxide precursors L-arginine and L-arginine L-glutamate do not alter the activity of cytolysis enzymes, reduce lipid peroxidation that correlates with indices of antioxidant protection, increase enzymatic activity in mitochondria and reduce endotoxemia. NO-synthase blockade by L-NAME increases endotoxemia, inhibits detoxification process in the liver, reduces the activity of electron transport enzymes in mitochondria, activation of lipids peroxodation reducing protective reserves of antioxidant system that is accompanied by low levels of NO2 ЎҐ in blood and liver.

Keywords: nitric oxide, liver, L-arginine, L-arginine Lglutamate,L-NAME.


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